Crosstalk pathways between Toll-like receptors and the complement system.
Crosstalk pathways between Toll-like receptors and the complement system.
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DOI：
10.1016/j.it.2010.01.002
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发表时间：
2010-04
影响因子：
16.8
通讯作者：
Lambris JD
中科院分区：
文献类型：
--
作者：
Hajishengallis G;Lambris JD
Toll 样受体 (TLR) 和补体是关键的先天防御系统，在感染后会迅速触发。尽管这两个系统主要作为独立的实体进行研究，但越来越多的证据表明补体和 TLR 信号通路之间存在广泛的串扰。对这些数据的分析表明，补体-TLR 相互作用分别通过协同或拮抗相互作用增强先天免疫或调节过度炎症。然而，某些病原体利用补体和 TLR 进行通讯的功能作为一种手段，以有利于病原体持续存在的方式改变宿主反应。进一步阐明补体和 TLR 之间的调节联系对于理解它们在健康和疾病中的复杂作用至关重要。
The Toll-like receptors (TLRs) and complement are key innate defense systems that are rapidly triggered upon infection. Although both systems have been investigated primarily as separate entities, an emerging body of evidence indicates extensive crosstalk between complement and TLR signaling pathways. Analysis of these data suggests that the complement–TLR interplay reinforces innate immunity or regulates excessive inflammation, through synergistic or antagonistic interactions, respectively. However, the facility of complement and TLRs for communication is exploited by certain pathogens as a means to modify the host response in ways that favor the persistence of the pathogens. Further elucidation of regulatory links between complement and TLRs is essential for understanding their complex roles in health and disease.
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