PROXIMAL-DISTAL PATTERN-FORMATION IN DROSOPHILA - GRADED REQUIREMENT FOR DISTAL-LESS GENE ACTIVITY DURING LIMB DEVELOPMENT
PROXIMAL-DISTAL PATTERN-FORMATION IN DROSOPHILA - GRADED REQUIREMENT FOR DISTAL-LESS GENE ACTIVITY DURING LIMB DEVELOPMENT
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DOI：
10.1007/bf02438941
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发表时间：
1989-01-01
期刊：
影响因子：
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通讯作者：
JURGENS, G
中科院分区：
文献类型：
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作者：
COHEN, SM;JURGENS, G
果蝇所有成年肢体的发育都取决于Distal-less基因的活性。我们在这里报告的表型表征的一些亚形态远端的等位基因，这表明有一个分级的要求远端的活动在发展中的肢体。以前的分析表明，在早期原基的肢体成虫盘的细胞具有分级的近端-远端的位置信息，这取决于其表达的Distal-少基因的存在。总之，这些数据表明，远端少可能直接编码的分级位置信息，需要组织的近端-远端轴的发展肢体。
The development of all of the adult limbs in Drosophila depends upon the activity of the Distal-less gene. We report here the phenotypic characterization of a number of hypomorphic Distal-less alleles which indicates that there is a graded requirement for Distal-less activity in the developing limbs. Previous analysis of genetically mosaic animals indicated that cells in the early primordia of the limb imaginal discs possess a graded proximal-distal positional information which depends on the presence of the Distal-less gene for its expression. Taken together these data suggest that Distal-less may directly encode the graded positional information that is required to organize the proximal-distal axis of the developing limbs.