Future nanomedicine for the diagnosis and treatment of osteoarthritis.
Future nanomedicine for the diagnosis and treatment of osteoarthritis.
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DOI：
10.2217/nnm.14.138
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Hasty KA
中科院分区：
文献类型：
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作者：
Eichaker LR;Cho H;Duvall CL;Werfel TA;Hasty KA
目前对骨关节炎（OA）的治疗在很大程度上是姑息性的，直到关节完全功能失调和假体置换成为必要。在治疗药物或生物制剂最有可能发挥作用的早期阶段，需要有效的方法来诊断OA并监测其进展。治疗性纳米体和纳米颗粒具有无创检测、跟踪和治疗早期OA的潜力。由于关节软骨一旦降解就不能再生，在超顺磁性氧化铁纳米颗粒跟踪的辅助下，基于细胞的治疗是未来OA进展后期有吸引力的治疗方式，当需要显著的软骨置换时。本文将描述当前和未来的检测和无创治疗退行性骨关节炎的转化方法。
Current treatments for osteoarthritis (OA) are largely palliative until the joints become totally dysfunctional and prosthetic replacement becomes necessary. Effective methods are needed for diagnosing OA and monitoring its progression during its early stages, when the effects of therapeutic drugs or biological agents are most likely to be effective. Theranostic nanosomes and nanoparticles have the potential to noninvasively detect, track and treat the early stages of OA. As articular cartilage does not regenerate once it is degraded, cell-based treatments aided by superparamagnetic iron oxide nanoparticle tracking are attractive future treatment modalities for the later stages of OA progression, when significant cartilage replacement is needed. This article will describe the current and future translational approaches for the detection and noninvasive treatment of degenerative OA.