Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect.
Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect.
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DOI：
10.1016/j.it.2018.06.001
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发表时间：
2018-08
影响因子：
16.8
通讯作者：
Demaria S
中科院分区：
文献类型：
--
作者：
Rodríguez-Ruiz ME;Vanpouille-Box C;Melero I;Formenti SC;Demaria S
放射治疗作为局部肿瘤治疗已经使用了一百多年。偶尔观察到全身性抗肿瘤效应的发生，表现为照射野外的肿瘤消退（远位效应），但认为太罕见且不可预测，无法作为治疗目标。随着免疫疗法的出现，这种情况发生了变化。在接受放射治疗的患者中观察到显着的全身效应，以控制在免疫检查点阻断期间进展的肿瘤，激发了使用放射来克服原发性和获得性癌症对免疫疗法的抗性的兴趣。在这里，我们审查的免疫机制，负责局灶性辐射的能力，以促进抗肿瘤T细胞反应，介导肿瘤排斥反应，并在某些情况下，导致全身效应。
Radiotherapy has been used for over hundred years as a local tumor treatment. The occurrence of systemic anti-tumor effects manifesting as regression of tumors outside of the irradiated field (abscopal effect) was occasionally observed but deemed too rare and unpredictable to be a therapeutic goal. This has changed with the advent of immunotherapy. Remarkable systemic effects have been observed in patients receiving radiotherapy to control tumors that were progressing during immune checkpoint blockade, stimulating interest in using radiation to overcome primary and acquired cancer resistance to immunotherapy. Here we review the immunological mechanisms that are responsible for the ability of focal radiation to promote antitumor T cell responses that mediate tumor rejection and, in some cases, result in systemic effects.
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影响因子：
19
作者：
Ceccaldi R;Rondinelli B;D'Andrea AD
通讯作者：
D'Andrea AD
影响因子：
11.2
作者：
Burnette BC;Liang H;Lee Y;Chlewicki L;Khodarev NN;Weichselbaum RR;Fu YX;Auh SL
通讯作者：
Auh SL
影响因子：
11.2
作者：
Barsoum, Ivraym B.;Smallwood, Chelsea A.;Graham, Charles H.
通讯作者：
Graham, Charles H.
DOI：
10.1158/1078-0432.ccr-09-0265
发表时间：
2009-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dewan MZ;Galloway AE;Kawashima N;Dewyngaert JK;Babb JS;Formenti SC;Demaria S
通讯作者：
Demaria S
影响因子：
4.4
作者：
Chakraborty, M;Abrams, SI;Hodge, JW
通讯作者：
Hodge, JW