Rituximab-induced Acute Thrombocytopenia in a Patient with Follicular Lymphoma: A Case Report and Review of the Literature.
Rituximab-induced Acute Thrombocytopenia in a Patient with Follicular Lymphoma: A Case Report and Review of the Literature.
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DOI：
10.2169/internalmedicine.9628-17
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发表时间：
2018-04-15
期刊：
影响因子：
--
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Omura Y;Shimazu H;Takahashi T
利妥昔单抗是一种非常有效的药物，用于治疗B细胞淋巴瘤。利妥昔单抗诱导的急性血小板减少症是一种罕见的副作用，以前曾在少数恶性淋巴瘤患者中报道过，其机制仍不清楚。我们在此报告的情况下，74岁的男子谁被诊断为滤泡性淋巴瘤和发展严重的急性血小板减少症的第二天后，利妥昔单抗管理。也出现类似弥散性血管内凝血的凝血异常。当医生使用利妥昔单抗治疗高危患者时，应密切监测血小板计数，以避免可能的不良事件。
Rituximab is a highly effective agent that is used in the treatment of B-cell lymphoma. Rituximab-induced acute thrombocytopenia is a rare side effect that has previously been reported in a small number of patients with malignant lymphoma; its mechanism is still unknown. We herein report the case of a 74-year old man who was diagnosed with follicular lymphoma and who developed severe acute thrombocytopenia the day after the administration of rituximab. Coagulation abnormality, which mimicked disseminated intravascular coagulation, also appeared. When physicians use rituximab to treat high-risk patients, the platelet count should be closely monitored to avoid possible adverse events.
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