The role of JAGGED in shaping lateral organs
The role of JAGGED in shaping lateral organs
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DOI：
10.1242/dev.00949
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发表时间：
2004-03-01
期刊：
影响因子：
4.6
通讯作者：
Weigel, D
中科院分区：
文献类型：
--
作者：
Dinneny, JR;Yadegari, R;Weigel, D
生长的位置依赖性调节对于多细胞生物中器官的成形是重要的。我们的特点是JAGGED，一个基因，编码一个蛋白质与一个单一的C2H2锌指结构域，在控制拟南芥侧器官的形态发生的作用。JAGGED功能丧失导致器官边缘呈锯齿状。在叶片中，叶片区域受影响最严重。在萼片、花瓣和雄蕊中，最强的缺陷出现在远侧区域。通过监测细胞周期活动在发育中的花瓣与组蛋白4的表达，我们表明，JAGGED抑制组织的过早分化，这是必要的远端区域的形成。缺陷的定位与JAGGED的表达结构域重叠，其被限制于侧器官的生长区域。JAGGED的表达是显着缺席的隐蔽苞片，叶状器官的残余，在许多物种中，但通常不会在野生型拟南芥发展的花。如果错误表达，JAGGED可以诱导苞片的形成，这表明JAGGED从隐藏的苞片中被排除是拟南芥无苞片花的一个原因。
Position-dependent regulation of growth is important for shaping organs in multicellular organisms. We have characterized the role of JAGGED, a gene that encodes a protein with a single C2H2 zinc-finger domain, in controlling the morphogenesis of lateral organs in Arabidopsis thaliana. Loss of JAGGED function causes organs to have serrated margins. In leaves, the blade region is most severely affected. In sepals, petals and stamens, the strongest defects are seen in the distal regions. By monitoring cell-cycle activity in developing petals with the expression of HISTONE 4, we show that JAGGED suppresses the premature differentiation of tissues, which is necessary for the formation of the distal region. The localization of defects overlaps with the expression domain of JAGGED, which is restricted to the growing regions of lateral organs. JAGGED expression is notably absent from the cryptic bract, the remnant of a leaf-like organ that subtends the flower in many species but does not normally develop in wild-type Arabidopsis. If misexpressed, JAGGED can induce the formation of bracts, suggesting that the exclusion of JAGGED from the cryptic bract is a cause of bractless flowers in Arabidopsis.