Social jetlag and metabolic control in non-communicable chronic diseases: a study addressing different obesity statuses
Social jetlag and metabolic control in non-communicable chronic diseases: a study addressing different obesity statuses
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DOI：
10.1038/s41598-017-06723-w
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发表时间：
2017-07-25
影响因子：
4.6
通讯作者：
Crispim, Cibele Aparecida
中科院分区：
文献类型：
--
作者：
Mota, Maria Carliana;Silva, Catarina Mendes;Crispim, Cibele Aparecida
社交时差（衡量昼夜节律系统紊乱的指标）与肥胖有关，但其与非传染性慢性疾病 (NCCD) 代谢并发症的关系在文献中尚不清楚。我们研究了 NCCD 患者的社会时差与肥胖状况和代谢参数之间的关联。患有 NCCD（肥胖、系统性动脉高血压、2 型糖尿病或血脂异常）的患者 (n = 792) 到巴西米纳斯吉拉斯州乌贝兰迪亚市公共卫生服务诊所就诊。他们被分为三种肥胖状态： 非肥胖：BMI < 30 kg/m(2)；代谢健康肥胖（MHO）：BMI = 30 kg/m(2) 且代谢综合征高风险生物标志物少于三个；代谢不健康肥胖 (MUO)：BMI = 30 kg/m(2)，并且代谢综合征的三种或多种生物标志物具有高风险值。调整混杂变量后，所有受试者（β = 0.08，p = 0.03）和 MUO 受试者（β = 0.32，p < 0.001）中，社交时差与空腹血糖水平呈正相关。存在社交时差（> 1 小时）的患者表现出显着的超重比值比 (OR)（OR = 2.0，置信区间 (CI) = 1.2-3.6，p = 0.006）和 MUO（OR = 1.8，CI = 1.1-2.8，p = 0.01）。这些结果表明，社交时差与 NCCD 患者超重和相关代谢并发症的较高风险相关。
Social jetlag - a measure of disruption of the circadian system - has been linked to obesity, but its association with metabolic complications in non-communicable chronic diseases (NCCDs) is unknown in the literature. We examined the associations between social jetlag and obesity status and metabolic parameters among individuals with NCCDs. Patients (n = 792) with NCCDs (obesity, systemic arterial hypertension, type 2 diabetes mellitus or dyslipidaemia) attended clinics of the public health service of the city of Uberlandia, Minas Gerais State, Brazil. They were classified in three obesity statuses: non-obese: BMI < 30 kg/m(2); metabolically healthy obese (MHO): BMI = 30 kg/m(2) and less than three high-risk biomarkers for metabolic syndrome; and metabolically unhealthy obese (MUO): BMI = 30 kg/m(2) and with high-risk values on three or more biomarkers for metabolic syndrome. After adjustments for confounding variables, social jetlag was positively associated with fasting glucose levels among all subjects (beta = 0.08, p = 0.03) and MUO subjects (beta = 0.32, p < 0.001). Patients with social jetlag (> 1 h) presented a significant odds ratio (OR) of being overweight (OR = 2.0, confidence interval (CI) = 1.2-3.6, p = 0.006) and MUO (OR = 1.8, CI = 1.1-2.8, p = 0.01). These results suggest that social jetlag is associated with a higher risk of overweight and related metabolic complications in individuals with NCCDs.