Lack of susceptibility of various primates and woodchucks to hepatitis C virus.
Lack of susceptibility of various primates and woodchucks to hepatitis C virus.
复制标题
各种灵长类动物和土拨鼠对丙型肝炎病毒缺乏易感性。
DOI：
10.1111/j.1600-0684.1993.tb00697.x
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发表时间：
1993
影响因子：
0.7
通讯作者：
T. Shikata
中科院分区：
文献类型：
--
作者：
K. Abe;T. Kurata;Y. Teramoto;J. Shiga;T. Shikata
用来自感染丙型肝炎的黑猩猩的感染性血清静脉内接种五种不同的灵长类动物，包括食蟹猴、恒河猴、绿色猴、日本猴、多格拉狒狒和土拨鼠。在接种后6个月内，每周从这些动物中采集的血清样本的丙型肝炎病毒RNA和抗HCV均为阴性。此外，血清丙氨酸氨基转移酶保持在正常范围内，肝组织学正常。这项研究表明，这些灵长类动物和土拨鼠似乎对丙型肝炎病毒不敏感。
Five different species of primates including cynomolgus monkey, rhesus monkey, green monkey, Japanese monkey, and doguera baboon and woodchucks were inoculated intravenously with infectious serum from a chimpanzee infected with hepatitis C. Serum samples obtained weekly from these animals were negative for hepatitis C virus RNA and anti-HCV during six months following inoculation. Furthermore, serum alanine aminotransferase remained within normal limits, and normal liver histology was seen. This study indicates that these primates and woodchucks do not appear to be susceptible to hepatitis C virus.