Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers
Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers
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DOI：
10.1007/s00213-010-1897-5
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发表时间：
2011-02-01
影响因子：
3.4
通讯作者：
Critchley, Hugo D.
中科院分区：
文献类型：
--
作者：
Beacher, Felix D. C. C.;Gray, Marcus A.;Critchley, Hugo D.
急性色氨酸耗竭（ATD）降低了中枢5-羟色胺的水平。因此，ATD使5-羟色胺的认知效应得以研究，并对包括抑郁症在内的精神疾病的理解产生了影响。为了确定5-羟色胺在有意识（外显）和无意识/附带的情绪信息加工中的作用，本研究采用随机、双盲、交叉设计，共有15名健康女性参与。主观情绪记录在基线和4小时后，当参与者进行一个明确的情绪面部处理任务，和任务引发无意识处理的情绪厌恶和中性图像呈现下意识使用backwardmasking.ATD与血浆色氨酸在4小时的一个强大的减少，但没有影响情绪或自主生理。ATD与快乐面孔的吸引力评分显着降低和愤怒面孔的强度/唤醒评分衰减相关。ATD也减少了无意识知觉任务的整体反应时间，但与掩蔽刺激的情感内容没有相互作用。ATD并不影响掩蔽图像的突破知觉（识别准确性），ATD减弱了正面面孔的吸引力和威胁性面孔的负面强度，这表明5-羟色胺对正面和负面显著社会情绪线索的社会显著性的评估有特定的贡献。我们没有发现血清素影响负面情绪刺激的无意识处理的证据。这些新的发现涉及血清素在积极的社会和行为参与的意识方面，并扩展知识ATD对情绪感知的影响。
Acute tryptophan depletion (ATD) decreases levels of central serotonin. ATD thus enables the cognitive effects of serotonin to be studied, with implications for the understanding of psychiatric conditions, including depression.To determine the role of serotonin in conscious (explicit) and unconscious/incidental processing of emotional information.A randomized, double-blind, cross-over design was used with 15 healthy female participants. Subjective mood was recorded at baseline and after 4 h, when participants performed an explicit emotional face processing task, and a task eliciting unconscious processing of emotionally aversive and neutral images presented subliminally using backward masking.ATD was associated with a robust reduction in plasma tryptophan at 4 h but had no effect on mood or autonomic physiology. ATD was associated with significantly lower attractiveness ratings for happy faces and attenuation of intensity/arousal ratings of angry faces. ATD also reduced overall reaction times on the unconscious perception task, but there was no interaction with emotional content of masked stimuli. ATD did not affect breakthrough perception (accuracy in identification) of masked images.ATD attenuates the attractiveness of positive faces and the negative intensity of threatening faces, suggesting that serotonin contributes specifically to the appraisal of the social salience of both positive and negative salient social emotional cues. We found no evidence that serotonin affects unconscious processing of negative emotional stimuli. These novel findings implicate serotonin in conscious aspects of active social and behavioural engagement and extend knowledge regarding the effects of ATD on emotional perception.