Effects of sucrose, glucose and fructose on peripheral and central appetite signals
Effects of sucrose, glucose and fructose on peripheral and central appetite signals
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DOI：
10.1016/j.regpep.2008.06.008
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发表时间：
2008-10-09
影响因子：
--
通讯作者：
Erlanson-Albertsson, Charlotte
中科院分区：
文献类型：
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作者：
Lindqvist, Andreas;Baelemans, Annernie;Erlanson-Albertsson, Charlotte
在西方世界，软饮料的消费量在过去三十年中有所增加，这是肥胖症增加的部分原因。软饮料最初是由蔗糖增甜的，现在是由其他含热量的甜味剂增甜的，如果糖。在这项研究中，我们研究了蔗糖，葡萄糖或果糖溶液对大鼠摄食量和体重的短期影响，以及对外周和中枢食欲信号的影响。大鼠接受含有任何一种糖的水和标准大鼠食物两周。仅接受水和标准食物的大鼠为对照组。所有提供糖溶液的老鼠都增加了它们的总热量摄入。尽管提供任何一种糖溶液的大鼠消耗的食物较少，但热量摄入量增加。由于热量摄入增加，高糖大鼠的血清游离脂肪酸、甘油三酯和胆固醇水平升高。此外，消耗糖溶液导致血清瘦素升高，血清PYY降低，下丘脑NPY mRNA下调。在接受果糖溶液的大鼠中，血清ghrelin增加。此外，消耗蔗糖或果糖溶液导致上调下丘脑CB1 mRNA。结论：葡萄糖、蔗糖或果糖溶液的摄入通过激活饥饿信号和抑制饱足信号以及激活奖赏成分，导致热量过度消耗和体重增加。这些糖溶液的增重作用可能通过下调NPY mRNA和增加血清瘦素而得以改善。(C)2008 Elsevier B.V.保留所有权利。
In the Western world, consumption of soft drinks has increased the last three decades and is partly responsible for the epidemic-like increase in obesity. Soft drinks, originally sweetened by sucrose, are now sweetened by other caloric sweeteners, such as fructose. In this study, we investigated the short-term effect of sucrose, glucose or fructose solutions on food intake and body weight in rats, and on peripheral and central appetite signals. Rats received water containing either of the sugars and standard rat chow for two weeks. Rats receiving water alone and standard chow were controls. All rats offered the sugar solutions increased their total caloric intake. The increased caloric intake occurred despite the fact that the rats offered either of the sugar solutions consumed less chow. As a consequence of the increased caloric intake, the sugar-drinking rats had elevated serum levels of free fatty acids, triglycerides and cholesterol. In addition, consuming sugar solutions resulted in increased serum leptin, decreased serum PYY and down-regulated hypothalamic NPY mRNA. Serum ghrelin was increased in rats receiving fructose solution. Moreover, consumption of sucrose or fructose solution resulted in up-regulated hypothalamic CB1 mRNA. Hypothalamic POMC mRNA was down-regulated in rats receiving glucose or fructose.In conclusion, consumption of glucose, sucrose or fructose solution results in caloric overconsumption and body weight gain through activation of hunger signals and depression of satiety signals as well as activation of reward components. The weight-promoting effect of these sugar solutions may possibly be ameliorated by the down-regulation of NPY mRNA and increased serum leptin. (C) 2008 Elsevier B.V. All rights reserved.