Usefulness of somatosensory evoked magnetic field dipole measurements by magnetoencephalography for assessing spinal cord function
Usefulness of somatosensory evoked magnetic field dipole measurements by magnetoencephalography for assessing spinal cord function
复制标题
DOI：
10.3171/spi.2002.96.1.0062
复制
发表时间：
2002-01-01
影响因子：
4.1
通讯作者：
Hara, M
中科院分区：
文献类型：
--
作者：
Goto, T;Tsuyuguchi, N;Hara, M
物体。客观评估感觉功能障碍是一项困难的工作。在本研究中。探讨应用脑磁图(MEG)测量体感诱发磁场(SSEMF)评价脊髓型颈椎病患者感觉障碍的可行性。对12例脊髓型颈椎病患者，采用160通道头盔式脑磁图系统刺激正中神经，对手术前后的SSEMF进行了测量。测定N20M的强度和潜伏期(首次反应发生在刺激后20ms)，并通过神经外科颈椎量表测定的感觉评分来评估手术前后文件感觉障碍的严重程度。此外，对11名健康人(对照组)进行了同样的N20m强度和潜伏期的测量。结果分析显示，12例脊髓型颈椎病患者术前N20m强度明显低于对照组(p<；0.005)。学生t检验)，此外，在术后感觉评分改善的6名患者中，N20M的强度显著增加(p<；0,005，配对t检验)。此外，感觉分数和偶极强度之间有显著的相关性(p<；0.001)。Spearman相关系数经等级检验)。由脑磁图测定的体感诱发磁场测量有助于客观和非侵入性地评估脊髓型颈椎病引起的感觉障碍。
Object. Objective assessment of sensory function disorders is difficult. In the present study. the authors investigated the possibility of assessing cervical myelopathy-induced sensory disorders by using magnetoencephalography (MEG) to measure somatosensory evoked magnetic fields (SSEMFs).Methods. In 12 patients with cervical myelopathy, SSEMFs were measured before and after surgery by using a 160-channel helmet-type MEG system to stimulate the median nerve. and the intensity and latency of N20m (first response occurring 20 msec after stimulation) were then determined, Additionally, the severity of file sensory disorder was assessed before and after surgery by obtaining sensory scores determined using the Neurosurgical Cervical Spine Scale. Furthermore, in 11 healthy individuals (control group), the intensity and latency of N20m were measured in the same fashion. Analysis of the results showed that the preoperative intensity of N20m in the 12 patients with cervical myelopathy was significantly lower than that demonstrated in the control patients (p < 0.005. Student t-test), In addition, of six patients in whom sensory scores improved postoperatively, there were significant increases in the intensity of N20m (p < 0,005, paired t-test). Furthermore, there was a significant correlation between sensory scores and dipole intensity (p < 0.001. Spearman correlation coefficient by rank test).Conclusions. Somatosensory evoked magnetic field measurements determined by MEG are useful in objectively and noninvasively assessing sensory disorders caused by cervical myelopathy.