Nucleolar organizer regions in human adrenocortical disorders.
Nucleolar organizer regions in human adrenocortical disorders.
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人类肾上腺皮质疾病中的核仁组织者区域。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
H. Nagura
中科院分区：
文献类型：
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作者：
H. Sasano;Y. Saito;I. Sato;N. Sasano;H. Nagura
应用银胶技术对39例正常肾上腺、双侧肾上腺皮质增生、肾上腺腺瘤和肾上腺癌的核仁组成区相关蛋白（AgNORs）进行了研究。在产生盐皮质激素和糖皮质激素的肾上腺皮质细胞中，每个细胞核的AgNORs平均数在正常肾上腺中最低，在腺瘤中最高，具有统计学显著性差异。双侧肾上腺皮质增生组织中AgNORs的平均数量介于正常肾上腺和腺瘤之间。经病理和临床证实的肾上腺皮质癌（12例）和腺瘤（17例）的AgNOR数无明显差异。在肾上腺皮质，AgNOR数可能与类固醇激素的产生增加，但似乎是在鉴别肾上腺皮质肿瘤恶性价值不大。
A silver colloid technique to demonstrate nucleolar organizer region-associated proteins (AgNORs) was performed on sections of 39 human adrenal glands, including normal adrenal cortex, bilateral adrenocortical hyperplasia, adenoma, and carcinoma. In mineralocorticoid and glucocorticoid-producing adrenocortical cells, the mean number of AgNORs per nucleus was lowest in the normal adrenal gland and highest in adenoma, with statistically significant differences. The mean number of AgNORs in bilateral adrenocortical hyperplasia was placed between that of normal adrenal and adenoma. AgNOR numbers in morphologically and clinically verified adrenocortical carcinoma (12 cases) were not different from those in adenoma (17 cases). In adrenal cortex, AgNOR numbers may be correlated with increased steroid hormone production but appear to be of little value in discerning malignancy in adrenocortical neoplasms.