Magnesium therapy decreased the rate of intrauterine fetal retardation, premature rupture of membranes and premature delivery in risk pregnancies treated with betamimetics.
Magnesium therapy decreased the rate of intrauterine fetal retardation, premature rupture of membranes and premature delivery in risk pregnancies treated with betamimetics.
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镁治疗降低了接受β受体激动剂治疗的高危妊娠中胎儿宫内发育迟缓、胎膜早破和早产的发生率。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
H. Algayer
中科院分区：
文献类型：
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作者：
A. Conradt;H. Weidinger;H. Algayer
在接受保胎药物治疗的患者中，发现宫内生长迟缓（IUR）婴儿的比例更高，这表明胎盘功能不全可能是早产和IUR的原因。为评价不同剂量β-受体激动剂和镁口服治疗的效果，对我院1979~1982年4,905例单胎妊娠中534例（10.9%）行安胎+环扎术（TC）的孕妇进行了回顾性研究。将镁添加到β-模拟剂中：自1979/1980年以来，每天口服3 - 6 mEq Mg2+，旨在"保护心脏"，自1981年以来，每天口服30 - 40 mEq Mg2+，以天冬氨酸镁的形式"支持宫缩"。我们比较了：平均年龄，胎次，补充镁的百分比和每年的妊娠结局;这些参数也与正常妊娠的参数进行了比较。在TC组中，（完成）妊娠期小于或等于36周的频率约为11%（正常妊娠仅为2%）。然而，这一比例逐年下降，从1979年的11.0%降至1982年的4.9%。1979年至1980年，TC组早产儿的胎膜早破（PROM）发生率约为6%。1981年降至2.2%，1982年降至1.6%（正常妊娠，约1%）。在TC组中，IUR（小于第10百分位数;巴伐利亚围产期评价; BPE）的频率在1979年为20.5%，1980年为17.5%。1981年降至8.8%，1982年降至10.6%（正常组，8.3 - 11.5%）。（250字处删节）
A higher percentage of intrauterine growth retarded (IUR) infants was found in patients treated with tocolytic drugs, indicating that placental insufficiency could be the cause of both premature labor and IUR. In order to evaluate the results of oral treatment with betamimetics and magnesium at different dosages, 534 (10.9%) pregnancies treated with tocolysis + cerclage (TC) of 4,905 single pregnancies managed in our hospital between 1979 and 1982 wee studied retrospectively. Addition of magnesium to betamimetics: since 1979/1980 3-6 mEq Mg2+ daily per os aimed towards 'cardioprotection', and since 1981, to 'support tocolyis' 30-40 mEq Mg2+ daily per os in the form of Mg aspartate. We compared: mean age, parity, percentage supplemented with Mg and outcome of pregnancy for each year; these parameters were also compared with those of normal pregnancies. The frequency of (completed) gestational periods less than or equal to 36 weeks was about 11% in the TC groups (only 2% in normal pregnancies). However, this was reduced annually from 11.0% in 1979 to 4.9% in 1982. The frequency of premature ruptured membranes (PROM) in premature infants was about 6% in the TC groups from 1979 to 1980. It was reduced to 2.2% in 1981 and to 1.6% in 1982 (normal pregnancies, about 1%). In the TC group the frequency of IUR (less than 10th percentile; Bavarian Perinatal Evaluation; BPE) amounted to 20.5% in 1979, and to 17.5% in 1980. It was reduced to 8.8% in 1981 and to 10.6% in 1982 (normal groups, between 8.3 and 11.5%).(ABSTRACT TRUNCATED AT 250 WORDS)