Serum β2-Microglobulin is Associated with Mortality in Hospitalized Patients with Exacerbated Chronic Obstructive Pulmonary Disease
Serum β2-Microglobulin is Associated with Mortality in Hospitalized Patients with Exacerbated Chronic Obstructive Pulmonary Disease
复制标题
血清 β2-微球蛋白与慢性阻塞性肺疾病加重住院患者的死亡率相关
DOI：
10.2147/copd.s243905
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发表时间：
2020-01-01
影响因子：
2.8
通讯作者：
Huang, Kewu
中科院分区：
文献类型：
--
作者：
Mao, Wenping;Wang, Jing;Huang, Kewu
目的：我们假设血清β 2微球蛋白（β 2M）水平升高是加重慢性阻塞性肺疾病（COPD）住院患者死亡率升高的一个独立因素。患者和方法：回顾性分析2012年12月31日至2017年12月28日在中国北京朝阳医院首次确诊的488例加重COPD住院患者。入院时测定或采集血清β 2M浓度等临床指标，随访至90 d。通过Cox回归分析探讨β 2M与30天和90天全因死亡率的关系，校正年龄、c反应蛋白值、n端脑利钠肽前体/100、呼吸衰竭[RF，定义为动脉氧分压（PaO2）]。
Purpose: We hypothesized that increased level of serum beta 2-microglobulin (beta 2M) is an independent factor associated with higher mortality in hospitalized patients with exacerbated chronic obstructive pulmonary disease (COPD).Patients and Methods: We retrospectively analyzed 488 hospitalized patients with exacerbated COPD as the first diagnosis at Beijing Chao-Yang hospital, P. R. China between December 31st, 2012 and December 28th, 2017. Concentrations of serum beta 2M and other clinical indexes were measured or collected on admission, and all patients were followed up to 90 days. The relationship between beta 2M and 30- and 90-day all-cause mortality was explored by Cox regression analysis adjusted for age, C-reactive protein values, N-terminal pro-brain natriuretic peptide/100, respiratory failure [RF, defined as partial arterial oxygen pressure (PaO2)