Zygotic regulation of maternal cyclin A1 and B2 mRNAs
Zygotic regulation of maternal cyclin A1 and B2 mRNAs
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DOI：
10.1128/mcb.21.5.1662-1671.2001
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发表时间：
2001-03-01
影响因子：
5.3
通讯作者：
Hartley, RS
中科院分区：
文献类型：
--
作者：
Audic, Y;Anderson, C;Hartley, RS
在囊胚中期过渡期？非洲爪蟾胚胎细胞周期由S期和M期之间的快速交替重塑为复杂的成体细胞周期。细胞周期重塑发生在合子转录启动后，并伴随着母体细胞周期蛋白A1和BZ的终末下调。我们在这里报告，细胞周期蛋白A1和B2蛋白的消失之前，其mRNA的快速去腺苷化。一种特殊的机制触发这种去腺苷化，这种机制依赖于3'非翻译区的离散区域，并需要合子转录。总之，这些结果强烈表明，合子依赖的细胞周期蛋白A1和细胞周期蛋白BZ mRNA的去腺苷化是这些蛋白质下调的原因。这些研究也提出了这样的可能性，即母细胞周期蛋白的合子控制在建立成体细胞周期中发挥作用。
At the midblastula transition? the Xenopus laevis embryonic cell cycle is remodeled from rapid alternations between S and M phases to become the complex adult cell cycle, Cell cycle remodeling occurs after zygotic transcription initiates and is accompanied by terminal downregulation of maternal cyclins A1 and BZ. We report here that the disappearance of both cyclin A1 and B2 proteins is preceded by the rapid deadenylation of their mRNAs. A specific mechanism triggers this deadenylation, This mechanism depends upon discrete regions of the 3' untranslated regions and requires zygotic transcription, Together, these results strongly suggest that zygote-dependent deadenylation of cyclin A1 and cyclin BZ mRNAs is responsible for the downregulation of these proteins. These studies also raise the possibility that zygotic control of maternal cyclins plays a role in establishing the adult cell cycle.