Second-trimester maternal serum inhibin A concentration as an early marker for preeclampsia
Second-trimester maternal serum inhibin A concentration as an early marker for preeclampsia
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DOI：
10.1016/s0002-9378(99)70448-5
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发表时间：
1999-07-01
影响因子：
9.8
通讯作者：
Harrington, K
中科院分区：
文献类型：
--
作者：
Aquilina, J;Barnett, A;Harrington, K
目的：孕妇血清抑制素A浓度在子痫前期升高。这项研究的目的是调查这种关系是否早于子痫前期经典症状的出现。研究设计：对685名妊娠15 - 19周的21三体筛查数据进行回顾性分析。主要结局指标为先兆子痫和小于胎龄（中位数的2.0倍明显更容易发生先兆子痫（P < 0.00001））以及分娩小于胎龄婴儿(
OBJECTIVE: Maternal serum inhibin A concentration is elevated in established preeclampsia. The aim of this study was to investigate whether this relationship antedates the appearance of the classic signs of preeclampsia.STUDY DESIGN: A retrospective analysis was performed on trisomy 21 screening data from 685 women at between 15 and 19 weeks' gestation. The main outcome measures were preeclampsia and small for gestational age (2.0 multiples of the median were significantly more likely to acquire preeclampsia (P < .00001) and to be delivered of a small for gestational age infant (