Antibiotic use in relation to the risk of breast cancer
Antibiotic use in relation to the risk of breast cancer
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DOI：
10.1001/jama.291.7.827
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发表时间：
2004-02-18
影响因子：
120.7
通讯作者：
Taplin, SH
中科院分区：
文献类型：
--
作者：
Velicer, CM;Heckbert, SR;Taplin, SH
背景：抗生素的使用可能通过影响免疫功能、炎症和免疫功能而与乳腺癌的风险相关。雌激素和植物化学物质的代谢；然而，关于抗生素使用与风险之间关系的临床数据。乳腺癌是稀疏的。目的探讨抗生素使用与乳腺癌发病风险的关系。在1993年1月1日至2001年6月30日期间参加大型非营利性健康计划至少1年的2266名19岁以上原发性浸润性乳腺癌患者（病例）和7953名随机选择的女性健康计划成员（对照）中进行病例对照研究，频率与年龄和入组时间相匹配。病例从监测、流行病学和最终结果癌症登记处确定。通过计算机药房记录确定抗生素使用情况。主要结局指标抗生素使用程度与乳腺癌风险之间的关系。结果抗菌药物累积天数增加。根据年龄和入组时间调整后，使用与乳腺癌发生风险增加相关。对于增加使用的类别（0,1 - 50,51 - 100,101 - 500,501 -1000和大于或等于1001天），乳腺癌的优势比（95%置信区间）为1.00（参考），1.45(1.24-1.69),1.53(1.28-1.83),1.68(1.42-2.00),2.14（1.60-2.88）和2.07 （1.48-2.89）
Context Use of antibiotics may be associated with risk of breast cancer through effects on immune function, inflammation, and. metabolism of estrogen and phytochemicals; however, clinical data on the association between antibiotic use and risk of. breast cancer are sparse.Objective To examine the association between use of antibiotics and risk of breast cancer.Design, Setting, and Participants Case-control Study among 2266,women older than 19 years with primary, invasive breast cancer (cases) enrolled in a large, non-profit health plan for at least 1 year between January 1, 1993, and June 30, 2001, and 7953 randomly selected female health plan members (controls), frequency-matched to cases on age and length of enrollment. Cases were ascertained from the Surveillance, Epidemiology, and End Results cancer registry. Antibiotic use was ascertained from computerized pharmacy records.Main Outcome Measure Association between extent of antibiotic use and risk of breast cancer.Results Increasing cumulative-days of antibiotic. use were associated with increased risk of incident breast cancer, adjusted for age and length of enrollment. For categories of increasing use (0, 1-50, 51-100, 101-500, 501-1000, and greater than or equal to1001 days), odds ratios (95% confidence intervals) for breast cancer were 1.00 (reference), 1.45 (1.24-1.69), 1.53 (1.28-1.83), 1.68 (1.42-2.00), 2.14 (1.60-2.88),and 2.07 (1.48-2.89) (P