THE IMPACT OF GEOGRAPHICAL, CLINICAL, DIETARY AND RADIATION-INDUCED FEATURES IN EPIDEMIOLOGY OF THYROID-CANCER
THE IMPACT OF GEOGRAPHICAL, CLINICAL, DIETARY AND RADIATION-INDUCED FEATURES IN EPIDEMIOLOGY OF THYROID-CANCER
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DOI：
10.1016/0959-8049(93)90292-n
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发表时间：
1993-01-01
影响因子：
8.4
通讯作者：
EBER, O
中科院分区：
文献类型：
--
作者：
LANGSTEGER, W;KOLTRINGER, P;EBER, O
甲状腺癌占每年确认的所有癌症的不到1%，但发病率正在上升。甲状腺癌的流行病学和病因学的早期工作大部分是基于甲状腺癌可以作为一个实体来治疗的假设。认识到甲状腺内存在两种不同类型的内分泌细胞，这清楚地表明，对甲状腺恶性肿瘤的病因学和流行病学的任何讨论都必须考虑这些肿瘤的组织学分类。此外，由于缺乏标准化的发病率数据收集，组织学诊断的困难，隐匿性乳头状癌的诊断率不同，以及尸检的流行和技术，在比较甲状腺癌的发病率时，有困难的问题要考虑。到目前为止，只有相对较小比例的甲状腺癌病例可以在流行病学和病因学方面得到充分肯定的解释。与一般癌症一样，甲状腺癌的病因学和流行病学在大多数情况下仍然是未知的。
Cancer of the thyroid accounts for less than 1% of all cancers recognised each year, but the incidence is rising. Much of the early work of the epidemiology and aetiology of thyroid cancer was based on the assumption that thyroid cancer can be treated as an entity. The recognition that two distinct types of endocrine cell occur within the thyroid has made it clear that any discussion of the aetiology and epidemiology of thyroid malignancies must take into account the histological classification of these tumours. Moreover, there are difficult problems to be considered when comparing thyroid cancer incidence across tumour registries, because of a lack of standardisation of morbidity data collection, difficulties in histological diagnosis, varying rates of diagnosis of occult papillary carcinoma, and prevalence and techniques of autopsies. So far only a relatively small proportion of thyroid cancer cases can be explained with adequate certainty as regards epidemiology and aetiology. As in cancer in general, the aetiology and epidemiology of thyroid cancer in detail remains unknown in the majority of cases.