Mechanisms involved in breast cancer liver metastasis.
Mechanisms involved in breast cancer liver metastasis.
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DOI：
10.1186/s12967-015-0425-0
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发表时间：
2015-02-15
影响因子：
7.4
通讯作者：
Cai X
中科院分区：
文献类型：
--
作者：
Ma R;Feng Y;Lin S;Chen J;Lin H;Liang X;Zheng H;Cai X
肝转移是乳腺癌患者的常见病，然而，可用的治疗方法有限且无效。虽然乳腺癌细胞的肝脏特异性归巢是转移的重要特征，但肝转移的形成不是随机的。事实上，乳腺癌细胞因子有助于肝脏微环境。近年来，对乳腺癌肝转移（BCLM）的认识取得了重大突破。肝转移的过程由多个步骤组成，涉及来自乳腺癌细胞和肝脏微环境的各种因素。进一步了解乳腺癌细胞和肝脏微环境的作用对于指导未来的临床治疗工作至关重要。在这篇综述中，我们讨论了乳腺癌细胞和肝脏微环境对肝转移的贡献，旨在提高BCLM患者的治疗效果。
Liver metastasis is a frequent occurrence in patients with breast cancer; however, the available treatments are limited and ineffective. While liver-specific homing of breast cancer cells is an important feature of metastasis, the formation of liver metastases is not random. Indeed, breast cancer cell factors contribute to the liver microenvironment. Major breakthroughs have been achieved recently in understanding breast cancer liver metastasis (BCLM). The process of liver metastasis consists of multiple steps and involves various factors from breast cancer cells and the liver microenvironment. A further understanding of the roles of breast cancer cells and the liver microenvironment is crucial to guide future work in clinical treatments. In this review we discuss the contribution of breast cancer cells and the liver microenvironment to liver metastasis, with the aim to improve therapeutic efficacy for patients with BCLM.
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影响因子：
3.3
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BROWN, LF;BERSE, B;SENGER, DR
通讯作者：
SENGER, DR
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