Reported versus confirmed wheeze and lung function in early life
Reported versus confirmed wheeze and lung function in early life
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DOI：
10.1136/adc.2003.038539
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发表时间：
2004-06-01
影响因子：
5.2
通讯作者：
Custovic, A
中科院分区：
文献类型：
--
作者：
Lowe, L;Murray, CS;Custovic, A
目的：为了探讨家长报告的喘息（未经证实），医生证实的喘息，随后的肺function.Methods：儿童过敏性疾病（一个家长过敏性）的风险招募产前前瞻性地从出生后。在孩子出生后的前三年，如果他们的孩子有气喘，父母被要求联系研究小组。由初级保健医生或研究医生确认是否存在喘鸣。在3岁时完成呼吸问卷和特定气道阻力测量（sR（aw），身体体积描记器）。186（40.9%）的父母报告他们的孩子在出生后的前三年有喘息，130（28.6%）的喘息得到证实。共有428名儿童参加了为期三年的临床审查，其中274名（64%）成功进行了肺功能检查。从未发生喘鸣的儿童（n = 152; 1.03，1.00 - 1.06）和父母报告但未经证实的喘鸣的儿童（n = 36; 1.02，0.96 - 1.07，p = 1.00）的sR（aw）（kPa.s;几何平均值，95% CI）无显著差异。与无喘息史或未确诊喘息的儿童相比，经医生证实的喘息患儿的sR（aw）显著增高（n = 86; 1.17，1.11 ~ 1.22，p< 0.001）。结论：经医生证实的喘息患儿的肺功能显著低于经父母报告但未确诊的患儿和从未发生喘息的患儿。一部分父母可能不太了解医学专业人员所说的“喘息”一词的含义。
Aims: To investigate the relation between parentally reported wheeze ( unconfirmed), physician confirmed wheeze, and subsequent lung function.Methods: Children at risk of allergic disease ( one parent atopic) were recruited antenatally and followed prospectively from birth. During the first three years of life parents were asked to contact the study team if their child was wheezy. The presence of wheeze was confirmed or not by the primary care or study physician. Respiratory questionnaire and specific airway resistance measurement (sR(aw), body plethysmograph) were completed at age 3 years.Results: A total of 454 children were followed from birth to 3 years of age. One hundred and eighty six (40.9%) of the parents reported their child wheezing in the first three years of life, and in 130 (28.6%) the wheeze was confirmed. A total of 428 children attended the three year clinic review, of whom 274 (64%) successfully carried out lung function tests. There was no significant difference in sR(aw) (kPa.s; geometric mean, 95% CI) between children who had never wheezed ( n = 152; 1.03, 1.00 to 1.06) and those with a parentally reported but unconfirmed wheeze (n = 36; 1.02, 0.96 to 1.07, p = 1.00). sR(aw) was significantly higher in children with a physician confirmed wheeze ( n = 86; 1.17, 1.11 to 1.22, p< 0.001) compared to those with no history of wheeze or with unconfirmed wheeze.Conclusions: Children with physician confirmed wheeze have significantly poorer lung function compared to those with parentally reported but unconfirmed and those who have never wheezed. A proportion of parents may have little understanding of what medical professionals mean by the term "wheeze''.