Possible inhibitory role of prolactin-releasing peptide for ACTH release associated with running stress
Possible inhibitory role of prolactin-releasing peptide for ACTH release associated with running stress
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DOI：
10.1152/ajpregu.00345.2006
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发表时间：
2007-01-01
影响因子：
2.8
通讯作者：
Soya, Hideaki
中科院分区：
文献类型：
--
作者：
Ohiwa, Nao;Chang, Hyukki;Soya, Hideaki
乳酸阈值附近的运动会引起应激反应，定义为“跑步应激”。我们之前已经证明，跑步压力与大脑某些区域的激活有关，例如大脑区域。例如，下丘脑室旁核（PVN）和视上核，被认为在调节压力相关反应（包括跑步期间促肾上腺皮质激素的释放）中发挥着不可或缺的作用。因此，我们研究了催乳素释放肽 (PrRP) 的作用，该肽存在于腹外侧髓质和孤束核中，已知在跑步引起的 ACTH 释放过程中投射到 PVN。 PrRP 神经元中 c-Fos 的积累与跑步速度相关，在跑步压力下达到最大水平。脑室内注射中和性抗 PrRP 抗体会导致跑步应激期间血浆 ACTH 水平和血乳酸蓄积增加，但在约束应激期间则不会。外源性脑室内给予低剂量的 PrRP 具有相反的效果。因此，我们的结果表明，在跑步压力期间，含有 PrRP 的神经元以运动强度依赖性方式被激活，同样产生的内源性 PrRP 会减弱跑步压力期间 ACTH 的释放和血乳酸的积累。在这里，我们提供了一个新的视角来理解 PrRP 在与跑步压力相关的内分泌代谢反应中的作用。
Exercise around the lactate threshold induces a stress response, defined as "running stress." We have previously demonstrated that running stress is associated with activation of certain regions of the brain, e. g., the paraventricular hypothalamic nucleus (PVN) and supraoptic nucleus, that are hypothesized to play an integral role in regulating stress-related responses, including ACTH release during running. Thus we investigated the role of prolactin-releasing peptide (PrRP), found in the ventrolateral medulla and the nucleus of the solitary tract, which is known to project to the PVN during running-induced ACTH release. Accumulation of c-Fos in PrRP neurons correlated with running speeds, reaching maximal levels under running stress. Intracerebroventricular injection of neutralizing anti-PrRP antibodies led to increased plasma ACTH level and blood lactate accumulation during running stress, but not during restraint stress. Exogenous intracerebroventricular administration of low doses of PrRP had the opposite effects. Therefore, our results suggest that, during running stress, PrRP-containing neurons are activated in an exercise intensity-dependent manner, and likewise the produced endogenous PrRP attenuates ACTH release and blood lactate accumulation during running stress. Here we provide a novel perspective on understanding of PrRP in the endocrine-metabolic response associated with running stress.