Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila
Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila
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DOI：
10.1016/j.devcel.2019.03.016
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发表时间：
2019-06-03
影响因子：
11.8
通讯作者：
Leopold, Pierre
中科院分区：
文献类型：
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作者：
Boulan, Laura;Andersen, Ditte;Leopold, Pierre
器官如何与其他身体部位一起缩放还没有被机械地理解。我们已经解决了这个问题，使用果蝇成虫盘模型。当一个椎间盘域的生长受到干扰时，椎间盘的其他部分和其他椎间盘的生长会减慢，保持适当的椎间盘间和椎间盘内比例。我们在这里表明，松弛素样Dilp8是需要这种器官间的协调。我们的工作还揭示了应激反应转录因子Xrp1在dilp8上游将器官生长状态与全身生长反应联系起来方面起着关键作用。此外，我们发现，小核糖体亚基蛋白RpS12是触发Xrp1依赖的非自主反应所必需的。我们的工作表明，RpS12，Xrp1和Dilp8形成了一个独立的调控模块，确保了发育过程中器官内和器官间的生长协调。
How organs scale with other body parts is not mechanistically understood. We have addressed this question using the Drosophila imaginal disc model. When the growth of one disc domain is perturbed, other parts of the disc and other discs slow down their growth, maintaining proper inter-disc and intra-disc proportions. We show here that the relaxin-like Dilp8 is required for this inter-organ coordination. Our work also reveals that the stress-response transcription factor Xrp1 plays a key role upstream of dilp8 in linking organ growth status with the systemic growth response. In addition, we show that the small ribosomal subunit protein RpS12 is required to trigger Xrp1-dependent non-autonomous response. Our work demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development.