Circulating immune complexes of IgA type in dermatitis herpetiformis.
Circulating immune complexes of IgA type in dermatitis herpetiformis.
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疱疹样皮炎中 IgA 型循环免疫复合物。
DOI：
10.1111/1523-1747.ep12522539
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Provost,TT
中科院分区：
文献类型：
--
作者：
Zone,JJ;LaSalle,BA;Provost,TT
有一些证据表明疱疹样皮炎可能是由循环免疫复合物介导的。本研究试图定义这些复合物的抗体类别。直接免疫荧光检测表明，所有研究的患者均在真皮乳头层中出现 IgA 颗粒沉积。使用定性 Raji 细胞免疫荧光测定以及定量免疫放射测定检测血清免疫复合物。研究发现，与正常人相比，25 名疱疹样皮炎患者的 IgA 复合物水平较高 (p< .01)。疱疹样皮炎患者中还发现含有较高水平的 IgG 复合物，但统计显着性较低 (P< .1)。这些复合物与疱疹样皮炎发病机制的关系尚未确定。
There is some evidence that dermatitis herpetiformis may be mediated by circulating immune complexes. This study attempts to define the antibody class of these complexes. All patients studied demonstrated granular deposition of IgA in the papillary dermis on direct immunofluorescence. Serum immune complexes were detected using the qualitative Raji cell immunofluorescent assay, as well as the quantitative immunoradiometric assay. A group of 25 dermatitis herpetiformis patients was found to have higher levels of IgA containing complexes compared to a group of normals (p< .01). Higher levels of IgG containing complexes were also noted in dermatitis herpetiformis patients at a low level of statistical significance (P< .1). The relationship of these complexes to the pathogenesis of dermatitis herpetiformis is yet to be determined.