Variation among species in proteomic sulphur content is related to environmental conditions
Variation among species in proteomic sulphur content is related to environmental conditions
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DOI：
10.1098/rspb.2005.3441
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发表时间：
2006-05-22
影响因子：
4.7
通讯作者：
Baudouin-Cornu, Peggy
中科院分区：
文献类型：
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作者：
Bragg, Jason G.;Thomas, Dominique;Baudouin-Cornu, Peggy
蛋白质的元素组成影响生物体所需的不同元素的数量。在这里，我们认为硫含量的变化，全蛋白质组之间的19个细菌，122真细菌和10个真核生物的基因组已被完全测序。我们发现，不同物种的蛋白质硫含量差异很大，蛋白质组的平均硫含量和基因组碱基组成相关。有助于蛋白质组硫含量变化的力量似乎在不同物种的蛋白质中非常均匀地起作用。特别是，硫含量的orthopathic蛋白质往往与平均蛋白质组硫含量。在原核生物中，蛋白质组硫含量往往是更大的厌氧菌，相对于非厌氧菌。嗜热菌倾向于具有比非嗜热菌更低的蛋白质组硫含量，这与半胱氨酸和甲硫氨酸残基的热不稳定性一致。这项工作表明，持续的环境生长条件可以影响整个蛋白质组的元素组成的演变，这种方式可能对生物体用于构建蛋白质的硫的量产生重要影响。它扩展了先前的研究，这些研究证明了环境条件的瞬时变化与在这些条件下表达的蛋白质子集的元素组成之间的联系。
The elemental composition of proteins influences the quantities of different elements required by organisms. Here, we considered variation in the sulphur content of whole proteomes among 19 Archaea, 122 Eubacteria and 10 eukaryotes whose genomes have been fully sequenced. We found that different species vary greatly in the sulphur content of their proteins, and that average sulphur content of proteomes and genome base composition are related. Forces contributing to variation in proteomic sulphur content appear to operate quite uniformly across the proteins of different species. In particular, the sulphur content of orthologous proteins was frequently correlated with mean proteomic sulphur contents. Among prokaryotes, proteomic sulphur content tended to be greater in anaerobes, relative to non-anaerobes. Thermophiles tended to have lower proteomic sulphur content than non-thermophiles, consistent with the thermolability of cysteine and methionine residues. This work suggests that persistent environmental growth conditions can influence the evolution of elemental composition of whole proteomes in a manner that may have important implications for the amount of sulphur used by living organisms to build proteins. It extends previous studies that demonstrated links between transient changes in environmental conditions and the elemental composition of subsets of proteins expressed under these conditions.