REGIONAL SPECIFICITY OF PEAK HYPEREMIC RESPONSE IN PATIENTS WITH CONGESTIVE-HEART-FAILURE - CORRELATION WITH PEAK AEROBIC CAPACITY
REGIONAL SPECIFICITY OF PEAK HYPEREMIC RESPONSE IN PATIENTS WITH CONGESTIVE-HEART-FAILURE - CORRELATION WITH PEAK AEROBIC CAPACITY
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DOI：
10.1016/0735-1097(93)90549-g
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发表时间：
1993-11-01
影响因子：
24
通讯作者：
LEJEMTEL, TH
中科院分区：
文献类型：
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作者：
JONDEAU, G;KATZ, SD;LEJEMTEL, TH
目标.本研究的目的是比较充血性心力衰竭患者与年龄和性别匹配的正常受试者前臂和小腿的峰值反应性充血血流量。此外，我们还试图将心力衰竭患者的峰耗氧量与前臂和小腿的峰反应性充血方式相关联。背景关于充血性心力衰竭患者的前臂峰值反应性充血，已有不同的结果报道。由于训练显著增加正常受试者的峰值反应性充血流量，我们假设，在充血性心力衰竭患者中，由于劳力症状而减少行走，小腿峰值反应性充血流量将优先减弱，小腿血管系统的损伤可能与峰值耗氧量相关。方法.前臂和小腿血流测定静脉闭塞体积描记术在休息时和5分钟后的动脉闭塞46例充血性心力衰竭和7名年龄和性别匹配的正常人。在自行车测力计上进行分级运动时测量峰值耗氧量。结果充血性心力衰竭患者的小腿峰值反应性充血流量低于正常受试者（22 +/- 1 vs. 32.5 +/- 3.5 ml/min/100 ml，p < 0.001），而两组的前臂峰值反应性充血流量相似。小腿最大反应性充血流量与最大耗氧量呈线性相关（r = 0.58，p < 0.0001），而前臂最大反应性充血流量与最大耗氧量无线性相关。在静息状态下或在心力衰竭患者动脉闭塞5分钟后，前臂和小腿峰值反应性充血流量不相关。结论.充血性心力衰竭患者的小腿峰值反应性充血流量减少，而前臂峰值反应性充血流量与年龄和性别匹配的正常受试者相同。充血性心力衰竭患者小腿峰值反应性充血流量与峰值耗氧量呈线性相关，但前臂峰值反应性充血流量则不然。
Objectives. The aim of this study was to compare peak reactive hyperemic blood flows in the forearm and calf of patients with congestive heart failure and in age and gender matched normal subjects. In addition, we attempted to correlate peak oxygen consumption with forearm and calf peak reactive hyperemic hows in the patients with heart failure. Background. Disparate results have been reported regarding forearm peak reactive hyperemia in patients with congestive heart failure. Because training significantly increases peak reactive hyperemic flow in normal subjects, we hypothesized that in patients with congestive heart failure who curtail walking because of exertional symptoms, calf peak reactive hyperemic flow would be preferentially attenuated and that impairment of calf vasculature may correlate with peak oxygen consumption. Methods. Forearm and calf blood flows were measured by venous occlusive plethysmography at rest and after 5 min of arterial occlusion in 46 patients with congestive heart failure and 7 age- and gender-matched normal subjects. Peak oxygen consumption was measured during graded exercise on a bicycle ergometer. Results. Calf peak reactive hyperemic flow was lower in patients with congestive heart failure than in normal subjects (22 +/- 1 vs. 32.5 +/- 3.5 ml/min per 100 ml, p < 0.001), whereas forearm peak reactive hyperemic flows were similar in the two groups. Calf peak reactive hyperemic flow was linearly related to peak oxygen consumption (r = 0.58, p < 0.0001), but forearm peak reactive hyperemic flow was not. Forearm and calf peak reactive hyperemic flows were not related at rest or after 5 min of arterial occlusion in the patients with heart failure. Conclusions. Calf peak reactive hyperemic flow is reduced in patients with congestive heart failure, whereas forearm peak reactive hyperemic flow is identical to that of age and gender-matched normal subjects. Calf peak reactive hyperemic flow is linearly related to peak oxygen consumption in patients with congestive heart failure, but forearm peak reactive hyperemic flow is not.