Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers
Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers
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DOI：
10.1111/j.1365-2893.2011.01492.x
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发表时间：
2012-02-01
影响因子：
2.5
通讯作者：
Pan, C.
中科院分区：
文献类型：
--
作者：
Zou, H.;Chen, Y.;Pan, C.
. B型肝炎表面抗原（HBsAg）阳性母亲所生婴儿，被动主动免疫后仍有失败发生.在这种情况下，母亲B型肝炎DNA水平和其他危险因素的作用仍不清楚。本研究回顾性评估了HBsAg阳性母亲所生婴儿与免疫预防失败相关的病毒学和其他危险因素。2007年1月至2010年3月，我们回顾了869对母婴的临床和病毒学检测。所有婴儿出生后接受相同的被动主动免疫接种计划。失败的婴儿（在712个月大时HBsAg阳性）与在此期间检测时HBsAg阴性的婴儿进行比较。869例婴儿中，27例（3.1%）免疫失败，842例（96.9%）HBsAg阴性。当母亲分娩前HBV DNA水平分层时，
. In infants born to hepatitis B surface antigen (HBsAg)positive mothers, failure after passiveactive immunization still occurs. The role of maternal hepatitis B DNA level and other risk factors in this setting remains unclear. This study retrospectively evaluated virologic and other risk factors associated with immunoprophylaxis failure in infants born to HBsAg-positive mothers. Between January 2007 and March 2010, we reviewed the clinical and virologic tests in 869 motherinfant pairs. All infants received the identical passiveactive immunization schedule after birth. The failure infants (HBsAg positive at 712 months of age) were compared to infants who were HBsAg negative when tested during this time period. Among 869 infants, 27 (3.1%) infants were immunoprophylaxis failures and the other 842 (96.9%) infants remained HBsAg negative. When mothers pre-delivery HBV DNA levels were stratified to