Reproductive Biology and Endocrinology Open Access Tissue Engineering and Cell Based Therapies, from the Bench to the Clinic: the Potential to Replace, Repair and Regenerate
Reproductive Biology and Endocrinology Open Access Tissue Engineering and Cell Based Therapies, from the Bench to the Clinic: the Potential to Replace, Repair and Regenerate
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W. Fodor
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作者：
W. Fodor
再生生物学领域适用于再生医学，是一个日益扩大的研究领域，希望为传统药物甚至新的生物药物疗法无法有效治疗的疾病和/或损伤提供治疗性治疗。再生医学领域的广泛研究集中在细胞、组织和器官的发育上，目的是通过移植恢复功能。人们普遍认为，细胞、组织或器官能够比任何机械装置、重组蛋白治疗或化合物更好地履行适当的生理/代谢职责，从而最好地完成功能的替换、修复和恢复。目前正在研究几种策略，包括来自自体原代细胞分离的细胞疗法、来自已建立的细胞系的细胞疗法、来自各种干细胞的细胞疗法，包括骨髓/间充质干细胞、脐带血干细胞、胚胎干细胞，以及来自转基因动物的细胞、组织和器官。这篇小型综述并不是要详尽无遗，而是旨在强调上述四个研究领域的临床应用，并将解决一些关键进展和一些尚未克服的障碍，因为技术和科学提高了再生医学成为临床常规的可能性。
The field of Regenerative Biology as it applies to Regenerative Medicine is an increasingly expanding area of research with hopes of providing therapeutic treatments for diseases and/or injuries that conventional medicines and even new biologic drug therapies cannot effectively treat. Extensive research in the area of Regenerative Medicine is focused on the development of cells, tissues and organs for the purpose of restoring function through transplantation. The general belief is that replacement, repair and restoration of function is best accomplished by cells, tissues or organs that can perform the appropriate physiologic/metabolic duties better than any mechanical device, recombinant protein therapeutic or chemical compound. Several strategies are currently being investigated and include, cell therapies derived from autologous primary cell isolates, cell therapies derived from established cell lines, cell therapies derived from a variety of stem cells, including bone marrow/mesenchymal stem cells, cord blood stem cells, embryonic stem cells, as well as cells tissues and organs from genetically modified animals. This mini-review is not meant to be exhaustive, but aims to highlight clinical applications for the four areas of research listed above and will address a few key advances and a few of the hurdles yet to be overcome as the technology and science improve the likelihood that Regenerative Medicine will become clinically routine.