Determination of selected pharmaceuticals in tap water and drinking water treatment plant by high-performance liquid chromatography-triple quadrupole mass spectrometer in Beijing, China
Determination of selected pharmaceuticals in tap water and drinking water treatment plant by high-performance liquid chromatography-triple quadrupole mass spectrometer in Beijing, China
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中国北京自来水和饮用水处理厂中选定药物的高效液相色谱-三重四极杆质谱仪测定
DOI：
10.1007/s11356-014-3473-8
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发表时间：
2015-02-01
影响因子：
5.8
通讯作者：
Zhang, Li-Qiu
中科院分区：
文献类型：
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作者：
Cai, Mei-Quan;Wang, Rong;Zhang, Li-Qiu
建立了固相萃取-高效液相色谱-串联质谱法（SPE-HPLC-MS/MS）同时测定北京市自来水和某饮用水处理厂中14种多类药物的方法。目标化合物包括7种抗炎药、2种抗菌药、2种调脂药、1种抗癫痫药和1种激素。检测限（LOD）和定量限（LOQ）范围分别为0.01 - 1.80 ng/L和0.05 - 3.00 ng/L。还研究了日内和日间精密度、不同基质的回收率和基质效应。在所选的14种药物化合物中，有9种在北京市区自来水中检出，浓度最高达38.24ng/L（卡马西平），且在自来水中检出的药物浓度水平（大多数药物<5ng/L）低于国外的研究水平。此外，在原水和成品水中分别测定了10种和6种药物，浓度范围分别为0.10 - 16.23和0.13 - 17.17 ng/L。在DWTP中最常检测到五种化合物，即安替比林、卡马西平、异丙基安替比林、氨基比林和苯扎贝特。在DWTP过程中，碘是最高浓度的药物，高达53.30 ng/L。DWTP对大多数药物的去除率为81.2 - 99.5%，其次是卡马西平，去除率为55.4%，但对布洛芬和苯扎贝特没有效果。
A simultaneous determination method of 14 multi-class pharmaceuticals using solid-phase extraction (SPE) followed by high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS/MS) was established to measure the occurrence and distribution of these pharmaceuticals in tap water and a drinking water treatment plant (DWTP) in Beijing, China. Target compounds included seven anti-inflammatory drugs, two antibacterial drugs, two lipid regulation drugs, one antiepileptic drug, and one hormone. Limits of detection (LODs) and limits of quantitation (LOQs) ranged from 0.01 to 1.80 ng/L and 0.05 to 3.00 ng/L, respectively. Intraday and inter-day precisions, recoveries of different matrices, and matrix effects were also investigated. Of the 14 pharmaceutical compounds selected, nine were identified in tap water of Beijing downtown with the concentration up to 38.24 ng/L (carbamazepine), and the concentration levels of detected pharmaceuticals in tap water (<5 ng/L for most pharmaceuticals) were lower than previous studies in other countries. In addition, ten and six pharmaceuticals were measured in raw water and finished water at the concentration ranged from 0.10 to 16.23 and 0.13 to 17.17 ng/L, respectively. Five compounds were detected most frequently in DWTP, namely antipyrine, carbamazepine, isopropylantipyrine, aminopyrine, and bezafibrate. Ibuprofen was found to be the highest concentration pharmaceutical during DWTP, up to 53.30 ng/L. DWTP shows a positive effect on the removal of most pharmaceuticals with 81.2–99.5 % removal efficiencies, followed by carbamazepine with 55.4 % removal efficiency, but it has no effect for removing ibuprofen and bezafibrate.