Insulin sensitivity affects corticolimbic brain responses to visual food cues in polycystic ovary syndrome patients
Insulin sensitivity affects corticolimbic brain responses to visual food cues in polycystic ovary syndrome patients
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DOI：
10.1515/hmbci-2015-0048
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发表时间：
2015-11-01
影响因子：
1
通讯作者：
Van Vugt, Dean A.
中科院分区：
文献类型：
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作者：
Alsaadi, Hanin M.;Van Vugt, Dean A.
背景资料：本研究探讨了影响胰岛素敏感性的食欲调节脑区的视觉foodcuses.Materials和方法的反应：19名被诊断为多囊卵巢综合征（PCOS）被分为胰岛素敏感（n = 8）和胰岛素抵抗（n = 11）组的基础上的稳态模型评估胰岛素抵抗（HOMA 2-IR）。受试者接受功能性磁共振成像（fMRI），同时查看水或葡萄糖消耗后的食物图片。高热量（HC）或低热量（LC）的食物图片内和组间的皮质边缘血氧水平依赖（BOLD）的反应进行了比较。结果：BOLD反应的食物图片减少葡萄糖的挑战过程中，在许多皮质边缘脑区的胰岛素敏感，但不胰岛素抵抗的主题。此外，胰岛素抵抗的程度呈正相关，在内侧前额叶皮层（mPFC），眶额皮层（OFC），前扣带回和腹侧被盖区（VTA）的响应HC图片，并在背外侧前额叶皮层（DLPFC），mPFC，前扣带回，和背侧皮层响应LC图片后葡萄糖挑战。BOLD信号在OFC，中脑，海马，杏仁核后葡萄糖挑战与HOMA 2-IR在响应HC-LC pictures.Conclusion：我们得出结论，正常抑制皮质边缘脑反应的食物图片在葡萄糖挑战是妥协的胰岛素抵抗的科目。在餐后高胰岛素血症期间，大脑对食物图片的反应性增加，可能导致胰岛素抵抗受试者更大的非稳态饮食和永久肥胖。
Background: This study examined the effect of insulin sensitivity on the responsiveness of appetite regulatory brain regions to visual food cues.Materials and methods: Nineteen participants diagnosed with polycystic ovary syndrome (PCOS) were divided into insulin-sensitive (n = 8) and insulin-resistant (n = 11) groups based on the homeostatic model assessment of insulin resistance (HOMA2-IR). Subjects underwent functional magnetic resonance imaging (fMRI) while viewing food pictures following water or dextrose consumption. The corticolimbic blood oxygen level dependent (BOLD) responses to high-calorie (HC) or low-calorie (LC) food pictures were compared within and between groups.Results: BOLD responses to food pictures were reduced during a glucose challenge in numerous corticolimbic brain regions in insulin-sensitive but not insulin-resistant subjects. Furthermore, the degree of insulin resistance positively correlated with the corticolimbic BOLD response in the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), anterior cingulate and ventral tegmental area (VTA) in response to HC pictures, and in the dorsolateral prefrontal cortex (DLPFC), mPFC, anterior cingulate, and insula in response to LC pictures following a glucose challenge. BOLD signal in the OFC, midbrain, hippocampus, and amygdala following a glucose challenge correlated with HOMA2-IR in response to HC-LC pictures.Conclusion: We conclude that the normal inhibition of corticolimbic brain responses to food pictures during a glucose challenge is compromised in insulin-resistant subjects. The increase in brain responsiveness to food pictures during postprandial hyperinsulinemia may lead to greater non-homeostatic eating and perpetuate obesity in insulin-resistant subjects.