Kinetics of incorporation of O6-methyldeoxyguanosine monophosphate during in vitro DNA synthesis.
Kinetics of incorporation of O6-methyldeoxyguanosine monophosphate during in vitro DNA synthesis.
复制标题
体外 DNA 合成过程中 O6-甲基脱氧鸟苷单磷酸的掺入动力学。
DOI：
10.1021/bi00314a006
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发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Mitra,S
中科院分区：
文献类型：
--
作者：
Snow,ET;Foote,RS;Mitra,S
C^-甲基鸟嘌呤是一种重要的前致突变损伤，通过简单的甲基化致癌物直接甲基化DNA而产生（Loveless，1969; Pegg，1977; Lawley，1979; Singer，1979）。根据Loveless（1969）提出的CP-烷基鸟嘌呤是促突变的，间接的体外和体内实验（Abbott & Saffhill，1979; Lawley & Martin，1975; Coulondre &米勒，1977）支持了CP-烷基鸟嘌呤是促突变的想法。
C^-Methylguanine is an important promutagenic lesion produced by direct methylation of DNA by simple methylating carcinogens (Loveless, 1969; Pegg, 1977; Lawley, 1979; Singer, 1979). Following the proposal of Loveless (1969) that CP-alkylguanine is promutagenic, indirect in vitro and in vivo experiments (Abbott & Saffhill, 1979; Lawley & Martin, 1975; Coulondre & Miller, 1977) supported the idea that the