Matrix metalloproteinase-2 and-9 levels in obese patients
Matrix metalloproteinase-2 and-9 levels in obese patients
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DOI：
10.1080/10623320802228815
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Cicero, A. F. G.
中科院分区：
文献类型：
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作者：
Derosa, G.;Ferrari, I.;Cicero, A. F. G.
文献报道的数据揭示了基质金属蛋白酶（MMPs）作为脂肪形成调节剂的新功能。然而，它们的表达谱和在肥胖介导的脂肪组织发育过程中的细胞微环境中的作用仍然不清楚。作者推测，MMP-2和MMP-9水平可能在肥胖中异常，反映了细胞外基质（ECM）周转的改变。163名肥胖患者和165名对照者入选。测量了以下内容：体重指数（BMI）、腰围（WC）、空腹血糖（FPG）、空腹血浆胰岛素（FPI）、稳态模型评估（HOMA）指数、收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（Tg）、脂蛋白（a）（Lp（a））、以及MMP-2和MMP-9的血浆水平。BMI和WC显著增加（p
The data reported in literature revealed a novel function for matrix metalloproteinases ( MMPs) as modulators of adipogenesis. However, their expression profile and role in the cellular microenvironment during obesity-mediated adipose tissue development remain poorly defined. The authors hypothesized that MMP-2 and MMP-9 levels might be abnormal in obesity, reflecting alterations in extracellular matrix (ECM) turnover. One hundred and sixty three obese patients and 165 controls were enrolled. The following were measured: body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment (HOMA) index, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) (Lp(a)), and plasma levels of MMP-2 and MMP-9. A significant increase of BMI and WC (p