Physical activity and eye diseases. The Beijing Eye Study
Physical activity and eye diseases. The Beijing Eye Study
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DOI：
10.1111/aos.13962
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发表时间：
2019-05-01
影响因子：
3.4
通讯作者：
Jonas, Jost B.
中科院分区：
文献类型：
--
作者：
Wang, Ya Xing;Wei, Wen Bin;Jonas, Jost B.
目的评估体力活动量与眼部疾病患病率之间的关系。方法对北京眼科研究的参与者进行详细的眼科检查和访谈。通过标准化问卷评估身体活动。在3468名研究参与者中，有3031名（87.4%）人（年龄：64.6 ± 9.7岁;范围：50-93岁）的身体活动信息可用。在多变量分析中（回归系数r：0.41），较高的体力活动与较低的糖尿病视网膜病变患病率相关[p = 0.009;标准回归系数β：-0.05;非标准回归系数B：-15.7; 95%置信区间（CI）：-27.6，-3.90]调整年龄较小、居住在农村地区、教育水平较低、甘油三酯和低密度脂蛋白血浓度较低以及高密度脂蛋白血浓度较高、收缩压较高后，降低体重指数和降低抑郁评分。其他主要眼部疾病，如开角型青光眼（p = 0.25），闭角型青光眼（p = 0.59），核性白内障（p = 0.78），皮质性白内障（p = 0.54），后囊下白内障（p = 0.96）、视网膜静脉阻塞（p = 0.93）和中心性浆液性脉络膜病变（p = 0.39）与该模型中的体力活动无统计学相关性。较高的体力活动与年龄相关性黄斑变性患病率之间的相关性（p = 0.04; β：0.04; B：4.87; 95% CI：0.25，9.50）略显着。结论：高体力活动和少久坐的生活方式与糖尿病视网膜病变的低患病率相关，而其他主要眼部疾病如任何类型的白内障和青光眼、视网膜静脉阻塞和中心性浆液性脉络膜病变的发生在统计学上与体力活动或久坐的生活方式无关。
Purpose To assess associations between the amount of physical activity and the prevalence of ocular diseases. Methods The participants of the population-based Beijing Eye Study underwent a detailed ophthalmological examination and an interview. Physical activity was assessed in a standardized questionnaire. Results Out of 3468 study participants, information on their physical activity was available for 3031 (87.4%) individuals (age: 64.6 +/- 9.7 years; range: 50-93 years). In multivariate analysis (regression coefficient r: 0.41), higher physical activity was associated with a lower prevalence of diabetic retinopathy [p = 0.009; standardized regression coefficient beta: -0.05; non-standardized regression coefficient B: -15.7; 95% confidence interval (CI): -27.6, -3.90] after adjusting for younger age, rural region of habitation, lower level of education, lower blood concentrations of triglycerides and low-density lipoproteins and higher blood concentrations of high-density lipoproteins, higher systolic blood pressure, lower body mass index and lower depression score. Other major ocular diseases such as open-angle glaucoma (p = 0.25), angle-closure glaucoma (p = 0.59), nuclear cataract (p = 0.78), cortical cataract (p = 0.54), posterior subcapsular cataract (p = 0.96), retinal vein occlusions (p = 0.93) and central serous choroidopathy (p = 0.39) were not statistically associated with physical activity in that model. The association between higher physical activity and prevalence of age-related macular degeneration (p = 0.04; beta: 0.04; B: 4.87; 95% CI: 0.25, 9.50) was marginally significant. Conclusions Higher physical activity and less sedentary lifestyle were associated with a lower prevalence of diabetic retinopathy, while the occurrence of other major ocular diseases such as any type of cataract and of glaucoma, retinal vein occlusions and central serous choroidopathy was statistically independent of physical activity or a more sedentary lifestyle.