Impact of glycaemic index and dietary fibre on insulin sensitivity during the refeeding phase of a weight cycle in young healthy men
Impact of glycaemic index and dietary fibre on insulin sensitivity during the refeeding phase of a weight cycle in young healthy men
复制标题
DOI：
10.1017/s000711451200462x
复制
发表时间：
2013-05-14
影响因子：
3.6
通讯作者：
Bosy-Westphal, Anja
中科院分区：
文献类型：
--
作者：
Lagerpusch, Merit;Enderle, Janna;Bosy-Westphal, Anja
以前的研究表明，低血糖指数(LGI)饮食可能会改善胰岛素敏感性(IS)。正如已经显示的在重新喂养过程中IS的下降，我们假设LGI-V。在这一阶段，高GI(HGI)饮食可能会有有利的影响。在一项对照营养干预研究中，16名健康男性(年龄26.8(SD 4.1)岁，BMI 23.0(SD 1.7)kg/m(2))接受了1周的过度喂养、3周的能量限制和2周的+/-50%能量需求(50%碳水化合物、35%脂肪和15%蛋白质)的再喂养。在重新喂养期间，受试者被分成两组，分别接受高纤维LGI或低纤维HGI食物(GI40v.74，纤维摄入量65(SD6)vs.27(SD4)g/d)。两组在重新喂养后体重恢复相同(平均恢复70.5(SD 28.0)%)。能量限制可改善IS，再投喂可降低IS。胰岛素抵抗指数(HOMA(IR))、松田IS指数(松田IS指数(ISI))均高于胰岛素抵抗指数组(P均0.05)。总而言之，限制饮食和重新喂养造成的营养压力在健康的非肥胖受试者中显示出GI/纤维效应。富含纤维的LGI食物可以改善体重周期中脆弱的再进食阶段的葡萄糖代谢。
Previous studies suggest that a low-glycaemic index (LGI) diet may improve insulin sensitivity (IS). As IS has been shown to decrease during refeeding, we hypothesised that an LGI-v. high-GI (HGI) diet might have favourable effects during this phase. In a controlled nutritional intervention study, sixteen healthy men (aged 26.8 (SD 4.1) years, BMI 23.0 (SD 1.7) kg/m(2)) followed 1 week of overfeeding, 3 weeks of energy restriction and of 2 weeks refeeding at +/- 50% energy requirement (50% carbohydrates, 35% fat and 15% protein). During refeeding, subjects were divided into two matched groups receiving either high-fibre LGI or lower-fibre HGI foods (GI 40 v. 74, fibre intake 65 (SD 6) v. 27 (SD 4) g/d). Body weight was equally regained in both groups with refeeding (mean regain 70.5 (SD 28.0)% of loss). IS was improved by energy restriction and decreased with refeeding. The decreases in IS were greater in the HGI than in the LGI group (group x time interactions for insulin, homeostasis model assessment of insulin resistance (HOMA(IR)), Matsuda IS index (Matsuda(ISI)); all P0.05). In conclusion, nutritional stress imposed by dietary restriction and refeeding reveals a GI/fibre effect in healthy non-obese subjects. LGI foods rich in fibre may improve glucose metabolism during the vulnerable refeeding phase of a weight cycle.