Asymmetric Reduction of Cyclic Imines Catalyzed by a Whole-Cell Biocatalyst Containing an (S)-Imine Reductase
Asymmetric Reduction of Cyclic Imines Catalyzed by a Whole-Cell Biocatalyst Containing an (S)-Imine Reductase
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DOI：
10.1002/cctc.201300539
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发表时间：
2013-12-01
期刊：
影响因子：
4.5
通讯作者：
Turner, Nicholas J.
中科院分区：
文献类型：
--
作者：
Leipold, Friedemann;Hussain, Shahed;Turner, Nicholas J.
生物催化亚胺还原：全细胞重组E.利用Streptomyces sp. GF 3546菌株，建立了一个能产生（S）-选择性亚胺还原酶（IRED）的大肠杆菌系统。该生物催化剂用于对多种底物进行对映选择性还原，如二氢异喹啉和二氢-β-咔啉以及亚胺离子。
Biocatalytic imine reduction: A whole‐cell recombinant E. coli system, producing an (S)‐selective imine reductase (IRED) from Streptomyces sp. GF3546, is developed. This biocatalyst is used for the enantioselective reduction of a broad range of substrates such as dihydroisoquinolines and dihydro‐β‐carbolines as well as iminium ions.