Comparative Developmental Toxicity of New Aromatic Halogenated DBPs in a Chlorinated Saline Sewage Effluent to the Marine Polychaete Platynereis dumerilii
Comparative Developmental Toxicity of New Aromatic Halogenated DBPs in a Chlorinated Saline Sewage Effluent to the Marine Polychaete Platynereis dumerilii
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DOI：
10.1021/es401841t
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发表时间：
2013-10-01
影响因子：
11.4
通讯作者：
Zhang, Xiangru
中科院分区：
文献类型：
--
作者：
Yang, Mengting;Zhang, Xiangru
使用海水冲洗厕所可能会将高浓度的溴化物和碘化物引入城市污水处理厂，并导致在对污水进行氯化消毒时形成溴化和碘化消毒副产物。在之前的一项研究中，作者小组已经检测到许多溴化dbp的存在，并在氯化盐水污水中发现了五种新的芳香溴化dbp。氯化盐水废水中存在的溴化DBPs可能对海洋生态造成不利影响。本研究除了在氯化盐水污水中检测鉴定了另外7种新的芳香卤化DBPs外，还利用海洋多毛藻Platynereis dumerilii评价了它们的发育毒性。为了比较，我们还研究了一些已知的卤化DBPs的发育毒性。发育毒性的等级次序20卤代主要是2,5-dibromohydroquinone > 2, 6-diiodo-4-nitrophenol > = 2, 4, 6-triiodophenol > 4-bromo-2-chlorophenol > = 4-bromophenol > 2, 4-dibromophenol > = 2, 6-dibromo-4-nitrophenol > 2-bromo-4-chlorophenol > 2, 6-dichloro-4-nitrophenol > 2, 4-dichlorophenol > 2, 4, 6-tribromophenol > 3, 3-dibromo-4-hydroxybenzaldehyde >三溴甲烷> = 2,4,6-trichlorophenol > 2, 6-dibromophenol > 2, 6-dichlorophenol >碘乙酸> = tribromoacetic酸>溴乙酸>氯乙酸。以发育毒性数据为基础，建立定量构效关系（QSAR）。QSAR涉及两个物理化学性质描述符（log P和pK(a)）和两个电子描述符（最低未占用分子轨道能量和最高已占用分子轨道能量），以指示这些dbp的转运、生物吸收和生物相互作用。它可以很好地预测大多数dbp的发育毒性。
Using seawater for toilet flushing may introduce high levels of bromide and iodide into a city's sewage treatment works, and result in the formation of brominated and iodinated disinfection byproducts (DBPs) during chlorination to disinfect sewage effluents. In a previous study, the authors' group has detected the presence of many brominated DBPs and identified five new aromatic brominated DBPs in chlorinated saline sewage effluents. The presence of brominated DBPs in chlorinated saline effluents may pose adverse implications for marine ecology. In this study, besides the detection and identification of another seven new aromatic halogenated DBPs in a chlorinated saline sewage effluent, their developmental toxicity was evaluated using the marine polychaete Platynereis dumerilii. For comparison, the developmental toxicity of some commonly known halogenated DBPs was also examined. The rank order of the developmental toxicity of 20 halogenated DBPs was 2,5-dibromohydroquinone > 2,6-diiodo-4-nitrophenol >= 2,4,6-triiodophenol > 4-bromo-2-chlorophenol >= 4-bromophenol > 2,4-dibromophenol >= 2,6-dibromo-4-nitrophenol > 2-bromo-4-chlorophenol > 2,6-dichloro-4-nitrophenol > 2,4-dichlorophenol > 2,4,6-tribromophenol > 3,3-dibromo-4-hydroxybenzaldehyde > bromoform >= 2,4,6-trichlorophenol > 2,6-dibromophenol > 2,6-dichlorophenol > iodoacetic acid >= tribromoacetic acid > bromoacetic acid > chloroacetic acid. On the basis of developmental toxicity data, a quantitative structure-activity relationship (QSAR) was established. The QSAR involved two physical-chemical property descriptors (log P and pK(a)) and two electronic descriptors (the lowest unoccupied molecular orbital energy and the highest occupied molecular orbital energy) to indicate the transport, biouptake, and biointeraction of these DBPs. It can well predict the developmental toxicity of most of the DBPs tested.