EXCESSIVE OBESITY IN OFFSPRING OF PIMA INDIAN WOMEN WITH DIABETES DURING PREGNANCY
EXCESSIVE OBESITY IN OFFSPRING OF PIMA INDIAN WOMEN WITH DIABETES DURING PREGNANCY
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DOI：
10.1056/nejm198302033080502
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
KNOWLER, WC
中科院分区：
文献类型：
--
作者：
PETTITT, DJ;BAIRD, HR;KNOWLER, WC
研究了皮马印第安人儿童肥胖与母亲妊娠期糖尿病之间的关系。在49名怀孕期间患有糖尿病的妇女中，68名儿童的肥胖患病率高于134名随后患有糖尿病（糖尿病前期）的妇女的541名儿童或446名未患糖尿病的妇女的1326名儿童。在15-19岁时，58%的糖尿病患者的后代体重达到或超过理想体重的140%，而非糖尿病患者的后代体重达到或超过理想体重的17%，糖尿病前期患者的后代体重达到或超过理想体重的25%（P < 0.001）。后代的肥胖与母亲的糖尿病直接相关，因为这种关联基本上不受母亲肥胖的干扰。研究结果强烈表明，糖尿病妇女的后代的产前环境导致儿童和成年早期肥胖的发展。
The relation in Pima Indians between obesity in children and diabetes during pregnancy in their mothers was studied. Of 49 women who had diabetes during pregnancy, 68 children had a higher prevalence of obesity than 541 children of 134 women who subsequently had diabetes (prediabetics) or than 1326 children of 446 women who remained nondiabetic. At 15-19 yr of age, 58% of the offspring of diabetics weighed 140% or more of their desirable weight, as compared with 17% of the offspring of nondiabetics and 25% of those of prediabetics (P < 0.001). Obesity in the offspring was directly related to maternal diabetes, since the association was not substantially confounded by maternal obesity. The findings strongly suggest that the prenatal environment of the offspring of diabetic women results in the development of obesity in childhood and early adulthood.