NONSPECIFIC VAGINITIS - DIAGNOSTIC-CRITERIA AND MICROBIAL AND EPIDEMIOLOGIC ASSOCIATIONS
NONSPECIFIC VAGINITIS - DIAGNOSTIC-CRITERIA AND MICROBIAL AND EPIDEMIOLOGIC ASSOCIATIONS
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DOI：
10.1016/0002-9343(83)91112-9
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发表时间：
1983-01-01
影响因子：
5.9
通讯作者：
HOLMES, KK
中科院分区：
文献类型：
--
作者：
AMSEL, R;TOTTEN, PA;HOLMES, KK
由于缺乏统一的病例定义和实验室方法，许多先前对非特异性阴道炎的研究在其病因和临床表现方面产生了相互矛盾的结果。对397名育龄期女大学生进行了研究，并应用了一套明确的标准来区分非特异性阴道炎与其他形式的阴道炎和正常发现。使用这种标准，在高达25%的研究人群中诊断出非特异性阴道炎;在> 50%的非特异性阴道炎患者中识别出无症状疾病。非特异性阴道炎的临床诊断，基于简单的办公室程序，与阴道分泌物中阴道加德纳菌（阴道嗜血杆菌）的存在和浓度以及阴道分泌物中的特征性生化结果相关。非特异性阴道炎还与性活动史、既往滴虫病史、目前使用非屏障避孕方法，特别是使用宫内节育器相关。G.使用高选择性培养基从总人群的51.3%中分离出阴道分泌物，该培养基在阴道分泌物中检测到的微生物浓度低于先前使用的培养基。提出了标准临床使用的实用诊断标准。应用这些标准应有助于非特异性阴道炎的临床管理，并在进一步研究的微生物和生化相关性和发病机制，这种温和的，但相当普遍的疾病。
Numerous previous studies of nonspecific vaginitis have yielded contradictory results regarding its cause and clinical manifestations, due to a lack of uniform case definition and laboratory methods. Consecutive unselected female university students (397) were studied and sets of well defined criteria to distinguish nonspecific vaginitis from other forms of vaginitis and from normal findings were applied. Using such critiera, nonspecific vaginitis was diagnosed in up to 25% of the study population; asymptomatic disease was recognized in > 50% of those with nonspecific vaginitis. A clinical diagnosis of nonspecific vaginitis, based on simple office procedures, was correlated with both the presence and the concentration of Gardnerella vaginalis (Hemophilus vaginalis) in vaginal discharge, and with characteristic biochemical findings in vaginal discharge. Nonspecific vaginitis was also correlated with a history of sexual activity, a history of previous trichomoniasis, current use of nonbarrier contraceptive methods and, particularly, use of an intrauterine device. G. vaginalis was isolated from 51.3% of the total population using a highly selective medium that detected the organisms in lower concentration in vaginal discharge than did previously used media. Practical diagnostic criteria for standard clinical use are proposed. Application of such criteria should assist in clinical management of nonspecific vaginitis and in further study of the microbiologic and biochemical correlates and the pathogenesis of this mild but quite prevalent disease.