Allelic loss on chromosome 9q is associated with lymph node metastasis of primary breast cancer
Allelic loss on chromosome 9q is associated with lymph node metastasis of primary breast cancer
复制标题
DOI：
10.1111/j.1349-7006.1998.tb00649.x
复制
发表时间：
1998-09-01
期刊：
影响因子：
--
通讯作者：
Emi, M
中科院分区：
文献类型：
--
作者：
Minobe, K;Onda, M;Emi, M
9号染色体上的频繁等位基因丢失见于多种人类肿瘤;此外，在该染色体上已鉴定出两个基因（P16和PTC），其突变等位基因赋予某些遗传性癌症综合征的易感性。利用分布在9号染色体两臂的15个高度多态性微卫星标记，我们检测了96例原发性乳腺癌的等位基因丢失，以确定可能参与这种类型肿瘤的基因的位置，在37例肿瘤中观察到等位基因丢失（39%），详细的缺失定位确定了9 p21，9q22.3和9 q33的靶区域。9q22.3和9 q33的丢失与淋巴结转移的存在相关，在硬癌中观察到9q22.3的等位基因丢失比侵袭性较低的组织学类型更频繁。因此，9q22.3和9 q33区域的抑癌基因失活可能在乳腺癌的进展中起作用，特别是在淋巴结转移和硬癌的发生中。
Frequent allelic losses on chromosome 9 are seen in a wide variety of human tumors; moreover, two genes (P16 and PTC) whose mutant alleles confer predispositions to some inherited cancer syndromes have been identified on this chromosome. Using 15 highly polymorphic microsatellite markers distributed on both arms of chromosome 9, we tested 96 primary breast carcinomas for allelic loss in order to define the locations of genes that might be involved in this type of tumor, Allelic loss was observed in 37 of the tumors (39%) and detailed deletion mapping identified target regions at 9p21, 9q22.3 and 9q33. Losses at 9q22.3 and 9q33 were correlated with the presence of lymph node metastasis, and allelic loss at 9q22.3 was observed more frequently in scirrhous tumors than in less aggressive histologic types. Therefore, inactivation of tumor suppressor genes in 9q22.3 and 9q33 regions might play a role in progression of breast cancers, especially in metastasis to lymph nodes and in development of scirrhous turners.