T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice.
T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice.
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DOI：
10.1002/eji.201444602
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发表时间：
2014-12
影响因子：
5.4
通讯作者：
Wuelfing, Christoph
中科院分区：
文献类型：
--
作者：
Sinai, Parisa;Dozmorov, Igor M.;Song, Ran;Schwartzberg, Pamela L.;Wakeland, Edward K.;Wuelfing, Christoph
Changes in immune function during the course of systemic lupus erythematosus (SLE) are well characterized. Class-switched antinuclear antibodies are the hallmark of SLE, and T/B- cell interactions are thus critical. However, changes in immune function contributing to disease susceptibility are unknown. Here, we have analyzed primary T and B cells from a mouse model of SLE prior to the onset of disease. To allow cognate T-cell activation with low affinity, we have developed a lower potency peptide ligand for the OTII T-cell receptor. T and B-cell couples formed less frequently and retained their polarity less efficiently preferentially in response to low affinity stimulation in SLE-prone mice. This matched decreased recruitment of actin and Vav1 and an enhanced PKCΘ recruitment to the cellular interface in T cells. The induction of the germinal center B-cell marker GL7 was increased in T/B cell couples from SLE-prone mice when the T-cell numbers were limited. However, the overall gene expression changes were marginal. Taken together, the enhanced cell couple transience may allow a more efficient sampling of a large number of T/B cell couples, preferentially in response to limiting stimuli, therefore enhancing the immune reactivity in the development of SLE.
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DOI：
10.1073/pnas.0807309106
发表时间：
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