Exploratory analysis of the spatial distribution of adult glioma age-adjusted county incidence rates, Nebraska Medicine, 2009-2019.
Exploratory analysis of the spatial distribution of adult glioma age-adjusted county incidence rates, Nebraska Medicine, 2009-2019.
复制标题
DOI：
10.1093/nop/npad050
复制
发表时间：
2024-02
影响因子：
2.7
通讯作者：
中科院分区：
文献类型：
--
作者：
包括神经胶质瘤在内的中枢神经系统（CNS）癌症发病率较低，但死亡率较高。内布拉斯加州中枢神经系统癌症的年龄调整发病率高于全国水平。这项探索性研究是由神经胶质瘤患者询问该州内病例是否可能聚集而引发的，目的是确定是否有必要进行更深入的调查。
利用来自内布拉斯加医学中心的电子健康记录，我们确定了2009年1月1日至2019年11月1日期间确诊的内布拉斯加州成年（年龄≥19岁）神经胶质瘤患者。对患者的居住地址进行了地理编码和绘图，并与美国年度人口普查数据相结合，以计算县一级的年龄调整发病率（AAIR）。为保护患者身份，病例数少于5例的县被排除在外。使用ArcGIS软件进行地理编码和绘图。
在分析所包含的285例病例中，53.2%的地址通过精确匹配进行了地理编码，其余的则手动处理。病例出现在93个县中的47个县。在数据抑制后，11个县（228例）在视觉上聚集在内布拉斯加州的东部和中部，年龄调整发病率为每10万人0.85 - 5.66例。
由于该罕见癌症病例数量少导致发病率不稳定，以及需要抑制数据以保护患者隐私，该州许多县被排除在分析之外。然而，这项初步研究表明，内布拉斯加州中部和东部的神经胶质瘤发病率最高。接下来的步骤包括分析州癌症登记数据，以确保更完整地确定病例。
Central nervous system (CNS) cancers including gliomas have low incidence but high mortality. The age-adjusted incidence rate for CNS cancers is higher in Nebraska than nationally. This exploratory study was motivated by glioma patient inquiries about possible clustering of cases within the state to see if more in-depth investigation was warranted. Using electronic health records from Nebraska Medicine, we identified Nebraska adult (age ≥19) glioma patients diagnosed between January 1, 2009 and November 1, 2019. Patient residential addresses were geocoded, mapped, and combined with annual US Census data to compute age-adjusted incidence rates (AAIR) at the county level. Counties with fewer than five cases were excluded to protect patient identity. ArcGIS software was used for geocoding and mapping. Of the 285 cases included in the analysis, 53.2% were geocoded with exact match and the remainder were processed manually. Cases occurred in 47 of the 93 counties. After data suppression, 11 counties (228 cases) visually clustered in eastern and central Nebraska with AAIR ranging from 0.85 to 5.66 per 100 000. Many counties in the state were excluded from analysis of this rare cancer due to the small number of cases leading to unstable rates and the need to suppress data to protect patient privacy. However, this preliminary study suggests that glioma incidence is highest in central and eastern Nebraska. Next steps include analysis of state cancer registry data to ensure more complete case ascertainment.