Immobilized Regenerable Active Chlorine within a Zirconium-Based MOF Textile Composite to Eliminate Biological and Chemical Threats
Immobilized Regenerable Active Chlorine within a Zirconium-Based MOF Textile Composite to Eliminate Biological and Chemical Threats
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DOI：
10.1021/jacs.1c08576
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发表时间：
2021-09-30
影响因子：
15
通讯作者：
Farha, Omar K.
中科院分区：
文献类型：
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作者：
Cheung, Yuk Ha;Ma, Kaikai;Farha, Omar K.
最近由SARS-CoV-2疫情引起的全球卫生危机和令人震惊的化学战剂使用，突出表明有必要生产有效的防护服和口罩，以抵御生物危害和化学威胁。然而，多功能防护纺织品的开发仍然落后，无法为公众提供足够的保护。为了解决这一挑战，我们设计了多功能和可再生的n -氯基生物杀灭和解毒纺织品，使用坚固的锆金属有机骨架（MOF） UiO-66-NH2作为氯载体，可以很容易地涂在纺织纤维上。氯漂白将位于MOF连接体上的胺基转化为活性n -氯结构。纤维复合材料对革兰氏阴性菌（大肠杆菌）和革兰氏阳性菌（金黄色葡萄球菌）均表现出快速的生物杀灭活性，每种菌株在5分钟内最多减少7对数，对SARS-CoV-2在15分钟内减少5对数。此外，负载活性氯的MOF/纤维复合材料选择性地、快速地降解了半衰期小于3分钟的芥菜及其化学模拟物2-氯乙基硫醚（CEES）。这里设计的多功能mof为基础的纤维复合材料有潜力作为保护布抵御生物和化学威胁。
The most recent global health crisis caused by the SARS-CoV-2 outbreak and the alarming use of chemical warfare agents highlight the necessity to produce efficient protective clothing and masks against biohazard and chemical threats. However, the development of a multifunctional protective textile is still behind to supply adequate protection for the public. To tackle this challenge, we designed multifunctional and regenerable N-chlorine based biocidal and detoxifying textiles using a robust zirconium metal-organic framework (MOF), UiO-66-NH2, as a chlorine carrier which can be easily coated on textile fibers. A chlorine bleaching converted the amine groups located on the MOF linker to active N-chlorine structures. The fibrous composite exhibited rapid biocidal activity against both Gram-negative bacteria (E. coli) and Gram-positive bacteria (S. aureus) with up to a 7 log reduction within 5 min for each strain as well as a 5 log reduction of SARS-CoV-2 within 15 min. Moreover, the active chlorine loaded MOF/fiber composite selectively and rapidly degraded sulfur mustard and its chemical simulant 2-chloroethyl ethyl sulfide (CEES) with half-lives less than 3 minutes. The versatile MOF-based fibrous composite designed here has the potential to serve as protective cloth against both biological and chemical threats.