Comparative in vitro activities of ciprofloxacin and other 4-quinolones against Mycobacterium tuberculosis and Mycobacterium intracellulare
Comparative in vitro activities of ciprofloxacin and other 4-quinolones against Mycobacterium tuberculosis and Mycobacterium intracellulare
复制标题
环丙沙星与其他4-喹诺酮类药物抗结核分枝杆菌和胞内分枝杆菌的体外活性比较
DOI：
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发表时间：
1986
影响因子：
4.9
通讯作者：
M. Cynamon
中科院分区：
文献类型：
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作者：
C. Fenlon;M. Cynamon
采用琼脂稀释法测定环丙沙星、氧氟沙星、阿米替林和诺氟沙星对22株结核分枝杆菌的体外抗菌活性。90%的环丙沙星和氧氟沙星分离株的MIC分别为0.5和1 μ g/ml。氨氟沙星和诺氟沙星活性较低。琼脂稀释法测得90%的环丙沙星和氧氟沙星对20株胞内分枝杆菌的MIC分别为2和8 μ g/ml。
The in vitro activity of ciprofloxacin, ofloxacin, amifloxacin, and norfloxacin against 22 clinical isolates of Mycobacterium tuberculosis was evaluated by agar dilution. The MICs for 90% of the isolates of ciprofloxacin and ofloxacin were 0.5 and 1 microgram/ml, respectively. Amifloxacin and norfloxacin were less active. The MICs for 90% of the isolates of ciprofloxacin and ofloxacin against 20 clinical isolates of Mycobacterium intracellulare were determined by agar dilution to be 2 and 8 micrograms/ml, respectively.