Expanding the Chemical Space of Nonribosomal Peptide Synthetase-like Enzymes by Domain and Tailoring Enzyme Recombination.
Expanding the Chemical Space of Nonribosomal Peptide Synthetase-like Enzymes by Domain and Tailoring Enzyme Recombination.
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通过结构域扩展非核糖体肽合成酶样酶的化学空间和定制酶重组。
DOI：
10.1021/acs.orglett.8b01581
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Wang,ClayCC
中科院分区：
文献类型：
--
作者：
vanDijk,JohannesWA;Wang,ClayCC
探讨了定制酶与工程化杂合非核糖体肽合成酶样酶组合的潜力，并导致了新型天然产物的甲基化和异戊二烯化形式，突出了这种方法的可能性和局限性。
The potential of tailoring enzymes in combination with engineered hybrid nonribosomal peptide synthetase-like enzymes was explored and resulted in methylated and prenylated forms of novel natural products, highlighting the possibilities and limitations of this approach.