Plasma lipids and lipoproteins in Greenlandic west coast Eskimos.
Plasma lipids and lipoproteins in Greenlandic west coast Eskimos.
复制标题
格陵兰西海岸爱斯基摩人的血浆脂质和脂蛋白。
作者：
H. Bang;J. Dyerberg
对130名格陵兰西海岸爱斯基摩人的血脂和脂蛋白谱进行了检测，这些人的生活方式，尤其是饮食习惯，与原始爱斯基摩人非常接近，与西欧人有本质上的不同。选择受检者的年龄组是为了与西欧人中流行缺血性心脏病的年龄组相比较。将130名格陵兰西海岸爱斯基摩人(69名女性和61名男性)的血脂和脂蛋白测定结果与丹麦的类似检查结果进行了比较，其中包括25名居住在丹麦的女性爱斯基摩人。与丹麦对照组相比，爱斯基摩人的总脂、胆固醇、甘油三酯、β-脂蛋白和β-前脂蛋白浓度显著降低。对居住在丹麦的爱斯基摩人的研究发现，他们的血脂水平明显高于格陵兰岛的爱斯基摩人，与丹麦对照组持平。这强烈反对格陵兰爱斯基摩人低脂和脂蛋白浓度的遗传和环境原因。与其他血脂浓度较低的社会一样，冠状动脉粥样硬化在格陵兰爱斯基摩人中很少见。尽管爱斯基摩人饮食中的脂肪摄入量很高，但他们的血脂浓度很低。这可以用爱斯基摩人饮食的特殊组成来解释，饱和脂肪酸含量低，不饱和脂肪酸含量高。除了冠状动脉粥样硬化，糖尿病在爱斯基摩人中非常罕见。这与血浆甘油三酯和β前体脂蛋白浓度非常低的相关性是诱人的，但纯粹是推测。
The plasma lipid and lipoprotein pattern has been examined in 130 Greenlandic west coast Eskimos with a life pattern, and especially with dietary habits, rather close to those of original Eskimos and essentially different from those of West Europeans. The age groups of the persons examined were chosen so as to be comparable with the age groups in which ischaemic heart disease prevails in West Europeans. The results of determination of plasma lipid and lipoproteins in the 130 Greenlandic west coast Eskimos, 69 women and 61 men, were compared with those of a similar examination in Denmark, including 25 female Eskimos living in Denmark. Significantly lower concentrations of total lipids, cholesterol, triglycerides, β-lipoproteins and pre-β-lipoproteins were found in Eskimos compared with Danish controls. The study on the Eskimos living in Denmark revealed plasma lipid values significantly higher than in Eskimos in Greenland and equal to those of Danish controls. This points strongly against a genetic and towards an environmental cause of the low lipid and lipoprotein concentrations in Greenlandic Eskimos. As in other societies with low plasma lipid concentrations, coronary atherosclerosis is rare among Greenlandic Eskimos. The Eskimos have low plasma lipid concentrations in spite of a high dietary intake of fat. This could be explained by the special composition of the Eskimo diet, with low content of saturated and high content of unsaturated fatty acids. Besides coronary atherosclerosis, diabetes mellitus is very rare among Eskimos. A correlation of this to the very low concentration of plasma triglycerides and pre-β-lipoproteins is tempting, but purely speculative.