Anxiety disorders in familial parkinsonism.
Anxiety disorders in familial parkinsonism.
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家族性帕金森症的焦虑症。
DOI：
10.1002/anxi.3070010505
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
R. Duvoisin
中科院分区：
文献类型：
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作者：
E. Lauterbach;R. Duvoisin
为了验证广泛型社交恐惧症患者多巴胺能、去甲肾上腺素能和/或多巴胺能神经功能失调的假设，我们研究了与健康志愿者相比，广泛型社交恐惧症患者中枢单胺功能的神经内分泌相关性。（芬氟拉明），多巴胺能（左旋多巴），和去甲肾上腺素21例DSM-III-R社交恐惧症患者（泛发型）和22名“从未患过精神病”志愿者在提供知情同意后参加了这项研究。社交恐惧症患者对芬氟拉明的皮质醇反应比志愿者相反，我们发现社交恐惧症患者和健康志愿者之间对芬氟拉明的催乳素反应、对可乐定的生长激素或去甲肾上腺素反应、对左旋多巴的催乳素反应或眨眼反应均无差异。研究结果表明，社交恐惧症患者可能表现出对多巴胺能系统的选择性超敏感性，但多巴胺能和去甲肾上腺素能连接似乎正常。进一步的挑战研究，更具体的血清素探针治疗前后可能有助于澄清的病理生理学的社交恐惧症。焦虑1：216-223（1994/1995）。© 1995 Wiley利斯公司
We examined neuroendocrine correlates of central monoamine function in patients with the generalized type of social phobia compared to healthy volunteers in order to test hypotheses of dopaminergic, noradrenergic, and/or serotonergic dysregulation in patients with this disorder.A double‐blind, placebo‐controlled, neuropharmacological challenge study was performed using probes for the serotonergic (fenfluramine), dopaminergic (levodopa), and noradrenergic (clonidine) systems.Twenty‐one patients with DSM‐III‐R social phobia (generalized type) and 22 “never mentally ill” volunteers participated in the study after providing informed consent.Patients with social phobia had an augmented cortisol response to fenfluramine administration compared to the volunteers. In contrast, we found that neither the prolactin response to fenfluramine, the growth hormone or norepinephrine response to clonidine, nor the prolactin or eye‐blink responses to levodopa, differed between patients with social phobia and healthy volunteers.The findings suggest that patients with social phobia may exhibit selective super‐sensitivity of serotonergic systems, but that dopaminergic and noradrenergic Junction appear normal. Further challenge studies with more specific serotonin probes before and after treatment may assist in the clarification of the pathophysiology of social phobia. Anxiety 1:216–223 (1994/1995). © 1995 Wiley‐Liss, Inc.