Campylobacter pylori: prospective analysis of clinical and histological factors associated with colonization of the upper gastrointestinal tract
Campylobacter pylori: prospective analysis of clinical and histological factors associated with colonization of the upper gastrointestinal tract
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幽门弯曲杆菌：与上消化道定植相关的临床和组织学因素的前瞻性分析
DOI：
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发表时间：
1988
影响因子：
5.5
通讯作者：
E. Reitemeyer
中科院分区：
文献类型：
--
作者：
G. Börsch;G. Schmidt;M. Wegener;M. Sandmann;R. Adamek;F. Leverkus;E. Reitemeyer
抽象的。幽门弯曲杆菌（C.p.）在连续的149名接受上消化道内窥镜检查的患者中，前瞻性地研究了具有5个预先定义的记忆变量、7种消化不良症状和各种盲法评估的组织学标准的上消化道的定植。定殖通过活组织检查尿素酶试验和组织学搜索确定。C.p.阳性和C.p.阴性患者之间的吸烟状态和溃疡愈合药物治疗频率存在显著差异（P <0.05）（与C.p.呈正相关）。和抗生素（负相关），但不适用于任何其他既往数据或症状。这些数据进一步进行逐步多元逻辑回归分析。在组织学检查中，C.p.定植与胃窦和胃体部胃炎的程度显著相关（P <0.01），与胃窦和胃体部活检中的淋巴细胞浸润以及胃窦中性粒细胞分级也显著相关。我们得出结论，上消化道的C. p定植与胃窦的胃炎变化有关，尽管程度较小，但与体部粘膜有关。然而，一个特定的模式的症状，以预测C.p.殖民无法建立。
Abstract. The association of Campylobacter pylori (C.p.) colonization of the upper gastrointestinal tract with five predefined anamnestic variables, seven symptoms of dyspepsia, and various blindly evaluated histological criteria, was prospectively investigated in a consecutive series of 149 patients submitted to upper gastrointestinal tract endoscopy. Colonization was determined by biopsy urease tests and histological searches. Significant differences (P < 005) between C.p.‐positive and C.p.‐negative patients were found for smoker status and the frequency of therapy with ulcer‐healing drugs (positive association with C.p.) and antibiotics (negative association), but not for any other of the anamnestic data or symptoms. These data were further submitted to stepwise multiple logistic regression analyses. Concerning histological findings, C.p. colonization was significantly associated with the degree of antrum and body gastritis (P < 0·01), and also with lymphocellular infiltration in antrum and body biopsies and neutrophil cellular grading in gastric antra. We conclude that C.p. colonization of the upper gastrointestinal tract is associated with gastritic change of the antrum and, albeit to a lesser extent, of the body mucosa. However, a specific pattern of symptoms to predict C.p. colonization could not be established.
幽门弯曲杆菌胃炎：过去、现在和对未来的推测。
DOI：
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发表时间：
1987
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Graham,DY;Klein,PD
通讯作者：
Klein,PD