Health benefits of 4,4-dimethyl phytosterols: an exploration beyond 4-desmethyl phytosterols.
Health benefits of 4,4-dimethyl phytosterols: an exploration beyond 4-desmethyl phytosterols.
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DOI：
10.1039/c9fo01205b
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发表时间：
2019-12
期刊：
影响因子：
6.1
通讯作者：
Tao Zhang;Ruijie Liu;Ming Chang;Qingzhe Jin;Hui Zhang;Xingguo Wang
中科院分区：
文献类型：
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作者：
Tao Zhang;Ruijie Liu;Ming Chang;Qingzhe Jin;Hui Zhang;Xingguo Wang
4,4-二甲基植物甾醇在脂肪族a环的碳-4原子上有两个甲基。甲基对于内源性和外源性生物活性化合物的分子识别至关重要。植物甾醇因其公认的健康益处而受到全世界的关注。然而，4,4-二甲基植物甾醇不太受重视。最近的研究表明，4,4-二甲基植物甾醇对疾病预防具有许多有益作用，特别是参与内源性大麻素系统（ECS）。本综述的目的是总结和强调目前关于4,4-二甲基植物甾醇的结构和来源的信息，并提供详细的临床前研究，以评估其治疗各种疾病的潜力。未来对4,4-二甲基植物甾醇的研究应进一步证实其与ECS的关系，并直接为临床试验阐明其机制。
4,4-Dimethyl phytosterols possess two methyl groups at the carbon-4 atom of the aliphatic A-ring. The methyl groups are crucial for the molecular recognition of endogenous and exogenous bioactive compounds. Phytosterols have received worldwide attention owing to their recognized health benefits. However, 4,4-dimethyl phytosterols are less appreciated. Recent research studies revealed that 4,4-dimethyl phytosterols exert numerous beneficial effects on disease prevention, and are particularly involved in the endogenous cannabinoid system (ECS). The purpose of this review is to summarize and highlight the currently available information regarding the structures and sources of 4,4-dimethyl phytosterols, and to provide detailed preclinical studies performed to evaluate their potential for treating various diseases. Future research on 4,4-dimethyl phytosterols is warranted to confirm their relationship with the ECS, and to elucidate the mechanism directly toward clinical trials.