Effect of iloprost infusion on the resistance index of renal vessels of patients with systemic sclerosis.
Effect of iloprost infusion on the resistance index of renal vessels of patients with systemic sclerosis.
复制标题
输注伊洛前列素对系统性硬化症患者肾血管阻力指数的影响
DOI：
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发表时间：
1997
影响因子：
3.9
通讯作者：
F. M. Quarto di Palo
中科院分区：
文献类型：
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作者：
R. Scorza;R. Rivolta;B. Mascagni;V. Berruti;S. Bazzi;D. Castagnone;F. M. Quarto di Palo
目标
使用彩色血流多普勒超声检查伊洛前列素（一种稳定的前列环素类似物）对系统性硬化症（SSc）患者肾血流的影响。
方法
该药物的急性作用在 10 名耐药指数 (RI) 水平升高的 SSc 患者中进行了研究（所有报告的 RI 值均乘以 100）。伊洛前列素静脉注射（2 ng/kg/min，持续 8 小时）。为了研究长期用药的影响，16 名 SSc 患者被随机分为 2 组，每组 8 例。第一组在 6 个月内接受 9 次伊洛前列素输注治疗。第二组接受缓释硝苯地平（40 毫克/天）治疗 6 个月。
结果
急性治疗后，叶间动脉 RI（中位数 67 vs 61；p = 0.02）和皮质血管 RI（中位数 65 vs 54；p = 0.001）降低。在长期用药中，硝苯地平不会改变 RI 值，而伊洛前列素会降低叶间（中位 69 vs 61；p < 0.03）和皮质动脉（中位 66 vs 58：p < 0.01）的 RI。
结论
我们的研究结果表明伊洛前列素可能有助于治疗硬皮病肾血管痉挛。
OBJECTIVE
To investigate the effect of iloprost, a stable prostacycline analog, on kidney blood flow in patients with systemic sclerosis (SSc), using color flow Doppler sonography.
METHODS
The acute effect of the drug was studied in 10 patients with SSc with elevated resistance index (RI) levels (all RI values reported are multiplied by 100). Iloprost was administered intravenously (2 ng/kg/min for a period of 8 h). To study the effects of chronic drug administration, 16 patients with SSc were randomly assigned to 2 groups of 8 cases each. The first group was treated with 9 infusions of iloprost in 6 mo. The second group was treated with slow release nifedipine (40 mg/day) for 6 mo.
RESULTS
Interlobar artery RI (median 67 vs 61; p = 0.02) and cortical vessel RI (median 65 vs 54; p = 0.001) were reduced after acute treatment. In chronic drug administration, RI values were not modified by nifedipine, while iloprost reduced the RI of the interlobar (median 69 vs 61; p < 0.03) and cortical arteries (median 66 vs 58: p < 0.01).
CONCLUSION
Our findings suggest iloprost might be useful for treatment of scleroderma renal vasospasm.