Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of Abies georgei.
Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of Abies georgei.
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DOI：
10.1055/s-0030-1250550
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发表时间：
2011-05
期刊：
影响因子：
2.7
通讯作者：
Xianwen Yang;Yong-Li Li-Yong-Li-Li-2110436520;Su-mei Li;Yun-Heng Shen;Jun‐Mian Tian;Z. Zhu;Lin Feng;Liang-Chun Wu
中科院分区：
文献类型：
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作者：
Xianwen Yang;Yong-Li Li-Yong-Li-Li-2110436520;Su-mei Li;Yun-Heng Shen;Jun‐Mian Tian;Z. Zhu;Lin Feng;Liang-Chun Wu
对长苞冷杉地上部分进行了系统的植物化学研究，共鉴定出9个新化合物和72个已知化合物，其中包括4个单萜、4个倍半萜、25个黄酮、14个木脂素和34个其它化学成分。新化合物包括两个单萜（1和2），两个倍半萜（3和4），三个黄酮（5，6和7），和两个其他成分（8和9）。根据各种光谱数据确定了它们的化学结构。所有分离物进行了抗肿瘤和抗炎活性测试。新化合物9，4 '-二羟基-5，7-二甲氧基-8-甲基查耳酮（7）对QGY-7703肿瘤细胞表现出中度抗增殖作用（IC（50）= 17.6 µg/mL）。已知化合物异阿魏醛（67）对RAW 264.7巨噬细胞中脂多糖（LPS）诱导的NO产生表现出最强的抑制活性（IC（50）= 19.0 µg/mL）。长苞冷杉可能是有益的药物化合物的重要来源。
A systematic phytochemical investigation of the aerial parts of Abies georgei yielded nine new and 72 known compounds, including four monoterpenes, four sesquiterpenes, 25 flavonones, 14 lignans, and 34 other chemical constituents. The new compounds included two monoterpenes (1 and 2), two sesquiterpenes (3 and 4), three flavonones (5, 6, and 7), and two other components (8 and 9). Their chemical structures were established on the basis of various spectroscopic data. All the isolates were tested for antitumor and anti-inflammatory activities. The new compound 9,4'-dihydroxy-5,7-dimethoxy-8-methylchalcone (7) demonstrated a moderate antiproliferative effect on QGY-7703 tumor cells (IC (50) = 17.6 µg/mL). The known compound isoferulaldehyde (67) exhibited the strongest inhibitory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages (IC (50) = 19.0 µg/mL). Abies georgei may be a significant source of beneficial pharmaceutical compounds.