Neural development of the neuregulin receptor ErbB4 in the cerebral cortex and the hippocampus: preferential expression by interneurons tangentially migrating from the ganglionic eminences.
Neural development of the neuregulin receptor ErbB4 in the cerebral cortex and the hippocampus: preferential expression by interneurons tangentially migrating from the ganglionic eminences.
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DOI：
10.1093/cercor/13.3.252
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发表时间：
2003-03
期刊：
影响因子：
3.7
通讯作者：
Hau-Jie Yau;Hsiao-Fang Wang;Cary Lai;Fu-Chin Liu
中科院分区：
文献类型：
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作者：
Hau-Jie Yau;Hsiao-Fang Wang;Cary Lai;Fu-Chin Liu
受体酪氨酸激酶是一类重要的信号转导分子，已被证明在神经发育中起关键作用。我们在本研究中报道，神经调节蛋白受体ErbB4在大鼠端脑腹侧切向背侧迁移的中间神经元中优先表达。早在胚胎日(E) 13切向迁移开始时，就在内侧神经节隆起检测到ErbB4免疫反应性。由ErbB4和Dlx（切向迁移细胞的标记物）双重标记的细胞组成的显著ErbB4阳性迁移流在E16-E18沿中下区和边缘区从腹外侧向背内侧皮层推进。E20后，中下区erbb4阳性流向生发区转移，并进一步经皮层延伸至海马原基。在发育过程中，tbr1阳性谷氨酸能投射神经元不表达ErbB4。ErbB4在成年期大脑皮层和海马中被大多数parvalbumin阳性中间神经元和其他gaba能中间神经元亚群优先表达。ErbB4在切向迁移的中间神经元中的早发性和优先表达表明，神经调节蛋白/ErbB4信号可能调节远端脑中间神经元的发育和功能。
The receptor tyrosine kinases represent an important class of signal transduction molecules that have been shown to play critical roles in neural development. We report in the present study that the neuregulin receptor ErbB4 is preferentially expressed by interneurons that are migrating tangentially from the ventral to the dorsal rat telencephalon. ErbB4 immunoreactivity was detected in the medial ganglionic eminence as early as embryonic day (E) 13 at the inception of tangential migration. Prominent ErbB4-positive migratory streams consisting of cells double-labeled with ErbB4 and Dlx, a marker of tangentially migrating cells, were found to advance along the lower intermediate zone and the marginal zone from the ventrolateral to the dorsomedial cortex at E16-E18. After E20, the ErbB4-positive stream in the lower intermediate zone shifted towards the germinal zone and further extended via the cortex into the hippocampal primordium. ErbB4 was not expressed by Tbr1-positive glutamatergic projection neurons during development. ErbB4 was preferentially expressed by the majority of parvalbumin-positive interneurons and subsets of other GABAergic interneurons in the cerebral cortex and the hippocampus in adulthood. The early onset and preferential expression of ErbB4 in tangentially migrating interneurons suggests that neuregulin/ErbB4 signaling may regulate the development and function of telencephalic interneurons.